Yoosufani Z, Slavin J D, Hellman R M, Sethi S S, Spencer R P
J Nucl Med. 1987 Aug;28(8):1348-50.
A 67-yr-old woman had follicular thyroid carcinoma metastatic to several osseous sites. There was also evidence of functioning pulmonary metastases. She was treated by total thyroidectomy and multiple doses of radioiodide (131I). Approximately 2.5 yr after the initial ablative dose, and a total dose of 820 mCi of sodium iodide 131I, preleukemic changes were noted in the bone marrow. This appears to be the second case of preleukemia that bears a temporal relationship to radioiodide therapy of thyroid carcinoma, and the first in which radioiodide alone has been used in therapy (without additional external radiation).
一名67岁女性患有滤泡性甲状腺癌，已转移至多个骨部位。也有功能性肺转移的证据。她接受了甲状腺全切除术和多剂放射性碘（131I）治疗。在初始消融剂量后约2.5年，总共给予820毫居里的碘化钠131I后，骨髓中出现了白血病前期变化。这似乎是第二例与甲状腺癌放射性碘治疗存在时间关联的白血病前期病例，也是首例仅使用放射性碘进行治疗（无额外外照射）的病例。
