Kemuriyama Shuhei, Aita Hideki, Maida Takeo, Kawamura Naohiko, Nezu Takashi, Iijima Masahiro, Endo Kazuhiko, Koshino Hisashi
Division of Geriatric Dentistry, Department of Human Biology and Pathophysiology, School of Dentistry, Health Sciences University of Hokkaido.
Division of Advanced Prosthodontics, Department of Oral Rehabilitation, School of Dentistry, Health Sciences University of Hokkaido.
Dent Mater J. 2023 Jan 31;42(1):11-18. doi: 10.4012/dmj.2022-081. Epub 2022 Sep 17.
Osteoporosis is considered a risk factor for osseointegration during implant treatment. Photofunctionalization of titanium has been shown to improve bone-based cell adhesion, proliferation, and functional expression, increasing the bone-implant contact rate and bone-implant integration strength. This study aimed to test the hypothesis that photofunctionalization is effective for implant fixation using an osteoporosis rat model. In the biomechanical push-in test, the bone-implant integration strength of the photofunctionalization treatment group was 1.53 times that of the control group (p<0.05). These values implied that photofunctionalization restored the ovariectomy-induced low bone-implant integration strength to normal states. In the micro-CT analysis, the BV/TV of the photofunctionalization treatment group was 1.32 times that of the control group (p<0.05). These values implied that photofunctionalization restored the ovariectomy-induced low peri-implant bone formation to normal states. These results indicate that photofunctionalization treatment increased peri-implant bone formation and bone-implant integration strength in ovariectomized rats.
骨质疏松症被认为是种植治疗过程中骨结合的一个风险因素。钛的光功能化已被证明可改善骨源性细胞的黏附、增殖和功能表达，提高骨-种植体接触率和骨-种植体结合强度。本研究旨在使用骨质疏松大鼠模型验证光功能化对种植体固定有效的假设。在生物力学推入试验中，光功能化治疗组的骨-种植体结合强度是对照组的1.53倍（p<0.05）。这些数值表明光功能化将卵巢切除诱导的低骨-种植体结合强度恢复到了正常状态。在显微CT分析中，光功能化治疗组的骨体积分数是对照组的1.32倍（p<0.05）。这些数值表明光功能化将卵巢切除诱导的种植体周围低骨形成恢复到了正常状态。这些结果表明，光功能化治疗增加了去卵巢大鼠种植体周围的骨形成和骨-种植体结合强度。
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