Department of Obstetrics and Gynaecology, Faculty of Medicine, University of Khartoum, Khartoum, Sudan.
Department of Obstetrics and Gynecology, Unaizah College of Medicine and Medical Sciences, Qassim University, Unaizah, Kingdom of Saudi Arabia.
BMC Pregnancy Childbirth. 2022 Sep 19;22(1):715. doi: 10.1186/s12884-022-05053-8.
The association between previous spontaneous abortion and preeclampsia is not yet fully understood. The current study was conducted to assess the association between previous spontaneous abortion and preeclampsia among pregnant women in Sudan.
A case-control study (involving 180 women in each study group) was conducted at Saad Abuelela Hospital, Khartoum, Sudan. The cases were pregnant women with preeclampsia, while the control group included healthy pregnant women. The participants' sociodemographic, obstetric, and clinical characteristics were assessed via a questionnaire.
There was no significant difference in the age, parity, education level, employment status, blood group, body mass index, and hemoglobin level between the patient and control groups. Forty (22.2%) women with preeclampsia and 68 (37.8%) women in the control group had a history of spontaneous abortion (p = 0.001). Multivariate logistic regression analysis (adjusted) revealed that women with a history of spontaneous abortion had a lower risk of preeclampsia than those without a history of spontaneous abortion [adjusted odds ratio (AOR) = 0.44, 95% confidence interval (CI) = 0.26‒0.73]. However, women with a history of preeclampsia had a higher risk of recurrence of preeclampsia (AOR = 1.92, 95% CI = 1.11‒3.32).
The present study revealed that previous spontaneous abortion reduced the risk of preeclampsia by 59.0%.
先前自然流产与子痫前期之间的关联尚未完全阐明。本研究旨在评估苏丹孕妇中先前自然流产与子痫前期之间的关联。
在苏丹喀土穆的 Saad Abuelela 医院进行了一项病例对照研究（每组纳入 180 名女性）。病例组为患有子痫前期的孕妇，对照组为健康孕妇。通过问卷评估参与者的社会人口统计学、产科和临床特征。
子痫前期组和对照组在年龄、产次、教育水平、就业状况、血型、体重指数和血红蛋白水平方面无显著差异。40 名（22.2%）子痫前期妇女和 68 名（37.8%）对照组妇女有自然流产史（p=0.001）。多变量逻辑回归分析（调整后）显示，有自然流产史的妇女发生子痫前期的风险低于无自然流产史的妇女[调整后比值比（AOR）=0.44，95%置信区间（CI）=0.26‒0.73]。然而，有子痫前期史的妇女复发子痫前期的风险更高（AOR=1.92，95%CI=1.11‒3.32）。
本研究表明，先前的自然流产可使子痫前期的风险降低 59.0%。
