既往自然流产与后续妊娠期间子痫前期之间的关联。
Association between previous spontaneous abortion and pre-eclampsia during a subsequent pregnancy.
作者信息
Sepidarkish Mahdi, Almasi-Hashiani Amir, Maroufizadeh Saman, Vesali Samira, Pirjani Reihaneh, Samani Reza O
机构信息
Department of Epidemiology and Reproductive Health, Reproductive Epidemiology Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran.
Division of Perinatology, Department of Obstetrics and Gynecology, Arash Hospital, Tehran University of Medical Sciences, Tehran, Iran.
出版信息
Int J Gynaecol Obstet. 2017 Jan;136(1):83-86. doi: 10.1002/ijgo.12008. Epub 2016 Nov 12.
OBJECTIVE
To determine the impact of a history of spontaneous abortion on pre-eclampsia during a subsequent pregnancy.
METHODS
A cross-sectional study enrolled pregnant women admitted to obstetrics and gynecology wards at 103 hospitals in Tehran, Iran for delivery between July 6 and July 21, 2015. Consenting participants were interviewed by midwives; data were collected using a five-part questionnaire and patients' medical records were retrieved. Patient data were analyzed by multiple logistic regression to identify variables associated with increased odds of pre-eclampsia.
RESULTS
In total, 5170 patients were interviewed and 252 had experienced pre-eclampsia. The number of previous spontaneous abortions was found to be associated with pre-eclampsia, and a higher number of previous spontaneous abortions was associated with increased odds of patients having experienced pre-eclampsia (adjusted odds ratio 1.28, 95% confidence interval 1.03-1.59; P=0.025).
CONCLUSION
A history of spontaneous abortion was associated with increased odds of pre-eclampsia during a subsequent pregnancy.
目的
确定自然流产史对后续妊娠期间子痫前期的影响。
方法
一项横断面研究纳入了2015年7月6日至7月21日期间在伊朗德黑兰103家医院妇产科病房住院分娩的孕妇。同意参与的参与者由助产士进行访谈；使用五部分问卷收集数据，并检索患者的病历。通过多因素逻辑回归分析患者数据，以确定与子痫前期几率增加相关的变量。
结果
总共对5170名患者进行了访谈，其中252名经历了子痫前期。发现既往自然流产次数与子痫前期有关，既往自然流产次数越多，患者经历子痫前期的几率越高（调整后的优势比为1.28，95%置信区间为1.03-1.59；P=0.025）。
结论
自然流产史与后续妊娠期间子痫前期几率增加有关。
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