Zhou G, Zhao M W, Cao Y P, Lin J H, Wang W G, Guo A, Tian H
Department of orthopedics, Peking University Third Hospital, Engineering Research Center of Bone and Joint Precision Medicine, Ministry of Education, Beijing 100191, China.
Department of Orthopedics, Peking University First Hospital, Beijing 100034, China.
Zhonghua Yi Xue Za Zhi. 2022 Sep 20;102(35):2799-2805. doi: 10.3760/cma.j.cn112137-20220406-00719.
To explore the influencing factors of health-related quality of life (HRQoL) in patients with knee osteoarthritis, and to analyze the non-surgical treatment of knee osteoarthritis. Demographic variables, treatment modalities, imaging data, and 12-item short form health survey (SF-12) scores of patients with knee osteoarthritis in orthopedic outpatient departments of five hospitals in Beijing from December 2017 to November 2018 were collected to analyze influencing factors of HRQoL and non-surgical treatment. A total of 2 034 patients were included. There were 530 males (26.1%) and 1 504 females (73.9%), with a mean age of (59.17±10.22) years. In terms of physical quality of life, female patients with knee osteoarthritis had lower physical components summary (PCS) compared with male patients (β=-0.521, =0.036); patients aged ≥64 years had lower PCS than those aged<55 years (β=-0.636, =0.026). Patients with an education of more than 12 years had higher PCS than those with less than 10 years (β=1.063, <0.001). Compared to patients with mild clinical symptoms, the PCS of patients with moderate clinical symptoms was lower (β=-0.860, =0.002), while the PCS of those with severe clinical symptoms was much lower (β=-1.126, <0.001). Patients treated with combination therapy had higher PCS than untreated patients (β=0.731, =0.005). In terms of mental quality of life, compared to patients engaged in sedentary work, the mental components summary (MCS) of patients engaged in mild manual labor jobs was lower (β=-0.712, =0.015); Compared to patients with a Charson comorbidity index of 0, patients with a Charlson comorbidity index ≥ 2 had lower MCS (β=-1.183, =0.007). In the past 12 months, 648 (31.9%), 143 (7.0%), 406 (20.0%), 680 (33.4%), 343 (16.9%), 681 (33.5%), 170 (8.4%) patients had used non-steroid anti-inflammatory drugs (NSAIDs), acetaminophen, glucosamine/chondroitin formulations, physical therapy, articular cavity puncture injection, traditional Chinese medicine treatment and exercise therapy, respectively. Total of 451 patients (22.2%) received monotherapy and 889 patients (43.7%) received combination therapy. The major non-surgical treatment methods for patients with knee osteoarthritis in Beijing are NSAIDs, physiotherapy and traditional Chinese medicine. Combination therapy is used more frequently than monotherapy. Physical quality of life is related to gender, age, education, severity of symptoms and treatment, while mental quality of life is related to occupational labor and comorbidities.
探讨膝骨关节炎患者健康相关生活质量（HRQoL）的影响因素，并分析膝骨关节炎的非手术治疗情况。收集2017年12月至2018年11月期间北京五家医院骨科门诊膝骨关节炎患者的人口统计学变量、治疗方式、影像学数据以及12项简短健康调查问卷（SF-12）评分，以分析HRQoL的影响因素和非手术治疗情况。共纳入2034例患者。其中男性530例（26.1%），女性1504例（73.9%），平均年龄为（59.17±10.22）岁。在生理生活质量方面，膝骨关节炎女性患者的生理综合评分（PCS）低于男性患者（β=-0.521，P=0.036）；年龄≥64岁的患者PCS低于年龄<55岁的患者（β=-0.636，P=0.026）。受教育年限超过12年的患者PCS高于受教育年限不足10年的患者（β=1.063，P<0.001）。与临床症状较轻的患者相比，临床症状中度的患者PCS较低（β=-0.860，P=0.002），而临床症状严重的患者PCS更低（β=-1.126，P<0.001）。接受联合治疗的患者PCS高于未治疗的患者（β=0.731，P=0.005）。在心理生活质量方面，与从事久坐工作的患者相比，从事轻度体力劳动工作的患者心理综合评分（MCS）较低（β=-0.712，P=0.015）；与查尔森合并症指数为0的患者相比，查尔森合并症指数≥2的患者MCS较低（β=-1.183，P=0.007）。在过去12个月中，分别有648例（31.9%）、143例（7.0%）、406例（20.0%）、680例（33.4%）、343例（16.9%）、681例（33.5%）、170例（8.4%）患者使用了非甾体类抗炎药（NSAIDs）、对乙酰氨基酚、氨基葡萄糖/软骨素制剂、物理治疗、关节腔穿刺注射、中医治疗和运动疗法。共有451例患者（22.2%）接受了单一疗法，889例患者（43.7%）接受了联合疗法。北京膝骨关节炎患者的主要非手术治疗方法是NSAIDs、物理治疗和中医。联合疗法的使用频率高于单一疗法。生理生活质量与性别、年龄、教育程度、症状严重程度和治疗有关，而心理生活质量与职业劳动和合并症有关。
