可见光辅助下使用羧酸和卤代琥珀酰亚胺对酮进行有机催化α-酰氧基化反应
Visible light-assisted organocatalytic α-acyloxylation of ketones using carboxylic acids and -halosuccinimides.
作者信息
Sakkani Nagaraju, Jha Dhiraj K, Whatley Emily, Zhao John C-G
机构信息
Department of Chemistry, University of Texas at San Antonio, One UTSA Circle, San Antonio, TX, 78249-0698, USA.
出版信息
Chem Commun (Camb). 2022 Oct 6;58(80):11308-11311. doi: 10.1039/d2cc04016f.
The α-acyloxylcarbonyl motif can be found in many important pharmaceuticals and biologically active natural products and their derivatives. In this manuscript, the direct synthesis of α-acyloxylketones from ketones and readily available carboxylic acids was realized using a photo-assisted halogen bond-mediated organocatalytic α-acyloxylation reaction. The desired α-acyloxylation products were obtained in good to high yields.
α-酰氧基羰基结构单元存在于许多重要的药物和生物活性天然产物及其衍生物中。在本论文中，通过光辅助卤素键介导的有机催化α-酰氧基化反应，实现了由酮和易得的羧酸直接合成α-酰氧基酮。所需的α-酰氧基化产物以良好至高收率得到。
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