有机催化的仲α-羟基膦酸酯的高度对映选择性合成。
Organocatalytic highly enantioselective synthesis of secondary alpha-hydroxyphosphonates.
作者信息
Dodda Rajasekhar, Zhao Cong-Gui
机构信息
Department of Chemistry, University of Texas at San Antonio, One UTSA Circle, San Antonio, Texas 78249-0698, USA.
出版信息
Org Lett. 2006 Oct 12;8(21):4911-4. doi: 10.1021/ol062005s.
Abstract
[reaction: see text] The first organocatalytic cross aldol reaction of ketones and diethyl formylphosphonate hydrate has been realized by using readily available l-prolinamide as the catalyst. Secondary alpha-hydroxyphosphonates have been synthesized in high enantioselective (up to >99% ee) and good diastereoselectivity.
摘要
[反应：见正文] 使用易于获得的L-脯氨酰胺作为催化剂，实现了酮与水合二乙基甲酰基膦酸酯的首例有机催化交叉羟醛反应。以高对映选择性（高达>99% ee）和良好的非对映选择性合成了仲α-羟基膦酸酯。
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