Araki H, Nojiri M, Kimura M, Aihara H
J Pharmacol Exp Ther. 1987 Aug;242(2):686-91.
The effect of the psychotropic drug minaprine on brain ischemia induced by a 5-min bilateral occlusion of the carotid arteries in the mongolian gerbil was studied. Severe impairment of memory was apparent when the passive avoidance test was carried out 2 days after the bilaterally induced ischemia. When minaprine in a dose of 50 mg/kg was given p.o. 30 min before the 5-min occlusion, there was a significant improvement in the memory impairment. The amplitude of the hippocampal theta waves decreased and Nissl's degradation was apparent in the CA1 neurons in the hippocampus from 2 days after the 5-min occlusion. Changes in the hippocampal neurons were exacerbated with time. When minaprine in a dose of 50 mg/kg was given there was no decrease in the amplitude of hippocampal theta waves, and Nissl's degradation and the destruction and disappearance of the CA1 neurons diminished considerably. All these findings indicate that minaprine warrants further study for possible clinical prescription.
研究了精神药物米那普明对蒙古沙鼠双侧颈动脉5分钟闭塞所致脑缺血的影响。在双侧诱导缺血2天后进行被动回避试验时，明显出现严重的记忆损害。当在5分钟闭塞前30分钟口服50mg/kg剂量的米那普明时，记忆损害有显著改善。5分钟闭塞后2天，海马θ波的振幅降低，海马CA1神经元出现明显的尼氏小体降解。海马神经元的变化随时间加剧。给予50mg/kg剂量的米那普明时，海马θ波的振幅没有降低，CA1神经元的尼氏小体降解以及破坏和消失明显减少。所有这些发现表明，米那普明值得进一步研究以确定其可能的临床处方。
