Piao Y, Mineshita S, Kuroiwa T, Koike Y
Department of Preventive Medicine, Tokyo Medical and Dental University, Japan.
Nihon Shinkei Seishin Yakurigaku Zasshi. 1995 Apr;15(2):157-63.
This study examines the effect of the psychotropic drug minaprine on memory impairment in Mongolian gerbils subjected to a 5-min bilateral common carotid artery occlusion, as assessed by their performance in an 8-arm radial maze task. Gerbils were initially trained on the 8-arm radial maze until their mean error was 0-1 for 5 days. This task was repeated before the ischemia was performed and again 7 days after it. Then the animals were immediately sacrificed for histopathological examination. Severe memory impairment occurred in the control gerbils; whereas when minaprine 75 mg/kg was given orally 30 min before the 5-min occlusion, memory impairment was significantly reduced. Histopathological analysis of the control gerbils showed nearly complete loss of the pyramidal neurons in the CA1 region of the hippocampus, whereas the minaprine-treated gerbils showed complete preservation of the pyramidal neurons. These findings suggest that minaprine has memory-impairment-prevention and neuroprotective effects against short-term ischemia in gerbils.
本研究通过蒙古沙鼠在八臂放射状迷宫任务中的表现，考察了精神药物米那普明对经历5分钟双侧颈总动脉闭塞的蒙古沙鼠记忆损伤的影响。沙鼠最初在八臂放射状迷宫上进行训练，直至其平均错误数连续5天为0-1。在缺血操作前重复此任务，缺血操作7天后再次重复。然后立即处死动物进行组织病理学检查。对照沙鼠出现严重的记忆损伤；而在5分钟闭塞前30分钟口服75mg/kg米那普明时，记忆损伤明显减轻。对照沙鼠的组织病理学分析显示海马CA1区锥体细胞几乎完全丧失，而米那普明治疗的沙鼠锥体细胞则完全保留。这些发现表明，米那普明对沙鼠短期缺血具有预防记忆损伤和神经保护作用。
