穗花杉双黄酮 E，一种来自澳大利亚入侵植物（穗花杉双黄酮 E，一种来自澳大利亚入侵植物（）的芳基二氢萘木脂素。

Echiumin E, an Aryl Dihydronaphthalene Lignan from the Australian Invasive Plant Paterson's Curse ().

机构信息

School of Pharmacy and Medical Science, Griffith University, Gold Coast Campus, Queensland 4222, Australia.

Menzies Health Institute Queensland, Griffith University, Gold Coast Campus, Queensland 4222, Australia.

出版信息

J Nat Prod. 2022 Oct 28;85(10):2474-2479. doi: 10.1021/acs.jnatprod.2c00151. Epub 2022 Sep 20.

DOI:10.1021/acs.jnatprod.2c00151

PMID:36126331

Abstract

A new aryl dihydronaphthalene lignan, echiumin E (), and four known compounds, echiumin A, globoidnan A, (-)-rabdosiin, and rosmarinic acid (-), were isolated from the Australian invasive plant (Paterson's curse) for the first time. Echiumin E () was characterized by 1D/2D NMR spectroscopy and MS spectrometry, with its absolute configuration assigned through comparison of experimental and TDDFT-calculated ECD data. Echiumin E () along with compounds - were screened in vitro against three cancer cell lines (SH-SY5Y, HeLa, and PC-3) and a prostate stromal (normal) cell line (WPMY-1) using a resazurin reduction assay. Echiumin E () was found to be active toward HeLa cells (IC 0.21 μM).

摘要

从澳大利亚入侵植物（帕特森的诅咒）中首次分离得到一个新的芳基二氢萘木脂素化合物echiumin E ()，以及四个已知化合物echiumin A、globoidnan A、(-)-rabdosiin 和迷迭香酸 (-)。Echiumin E ()通过 1D/2D NMR 光谱和 MS 光谱进行表征，并通过比较实验和 TDDFT 计算的 ECD 数据确定其绝对构型。Echiumin E ()与化合物 - 一起在体外使用 Resazurin 还原测定法针对三种癌细胞系（SH-SY5Y、HeLa 和 PC-3）和一种前列腺基质（正常）细胞系（WPMY-1）进行筛选。发现 echiumin E ()对 HeLa 细胞具有活性（IC 0.21 μM）。