长链非编码 RNA（lncRNA）核丰富丰富转录物 1（NEAT1）在免疫性疾病中的作用。
The role of long noncoding RNA (lncRNA) nuclear-enriched abundant transcript 1 (NEAT1) in immune diseases.
机构信息
Department of Gastroenterology, Affiliated Hospital of Jining Medical University, Jining Medical University, Jining, Shandong 272000, PR China.
Department of Gastroenterology, Affiliated Hospital of Jining Medical University, Jining Medical University, Jining, Shandong 272000, PR China..
出版信息
Transpl Immunol. 2022 Dec;75:101716. doi: 10.1016/j.trim.2022.101716. Epub 2022 Sep 17.
The long noncoding RNA (lncRNA) nuclear-enriched abundant transcript 1 (NEAT1) has been shown to be involved in the pathogenesis of several diseases. Herein, we discuss recent developments and insights into NEAT1 and its contribution to a variety of immune disorders. Our evaluations revealed that NEAT1's function in immune diseases seems to be focused on the modulation of paraspeckle expression and it is primarily associated with the nuclear retention of its mRNA. NEAT1 is also involved in the sequestration of paraspeckle proteins and in affecting the transcriptional expression of specific immune regulators. The expression of NEAT1 may be aberrantly upregulated in several immune pathologies, indicating that it could serve as a potential prognostic biomarker in these conditions. We summarized describing the expression changes and the role of NEAT1 in several immune diseases. We also described the mechanism of its regulation of the immune cell differentiation and function of NEAT1 in different disease.
长链非编码 RNA（lncRNA）核丰富丰富转录本 1（NEAT1）已被证明参与了多种疾病的发病机制。在此，我们讨论了 NEAT1 的最新研究进展和研究进展，以及它对各种免疫紊乱的贡献。我们的评估表明，NEAT1 在免疫疾病中的作用似乎集中在调节副染色质的表达上，并且主要与它的 mRNA 在核内的保留有关。NEAT1 还参与了副染色质蛋白的隔离，并影响特定免疫调节剂的转录表达。在几种免疫病理学中，NEAT1 的表达可能异常上调，表明它可能成为这些情况下的潜在预后生物标志物。我们总结了描述 NEAT1 在几种免疫疾病中的表达变化和作用。我们还描述了其调节免疫细胞分化和不同疾病中 NEAT1 功能的机制。
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