长非编码 RNA，富含核的转录本 1（NEAT1）在癌症和其他病理中的作用。
The Role of Long Non-coding RNA, Nuclear Enriched Abundant Transcript 1 (NEAT1) in Cancer and Other Pathologies.
机构信息
School of Kinesiology, Shanghai University of Sport, Shanghai, 200438, China.
School of Biomedical Sciences, University of Western Australia, Perth, WA, Australia.
出版信息
Biochem Genet. 2022 Jun;60(3):843-867. doi: 10.1007/s10528-021-10138-8. Epub 2021 Oct 24.
Nuclear enriched abundant transcript 1 (NEAT1), consisting of two kinds of lncRNAs of 3.7 kB NEAT1-1 and 23 kB NEAT1-2, can be highly expressed in organs and tissues such as the ovary, prostate, colon, and pancreas, and is involved in paraspeckle formation and mRNA editing and gene expression. Therefore, NEAT1 is a potential biomarker for the treatment of a variety of diseases, which may be caused by two factors (isoforms of NEAT1 and NEAT1 sponging miRNA as ceRNA). However, there is still much confusion about the mechanism and downstream effector between the abnormal expression of NEAT1 and various diseases. This review summarizes recent research progress on NEAT1 in cancer and other pathologies and provides a more reliable theoretical basis for the treatment of related diseases.
核富集丰富转录本 1（NEAT1），由两种长链非编码 RNA 3.7 kB NEAT1-1 和 23 kB NEAT1-2 组成，在卵巢、前列腺、结肠和胰腺等器官和组织中可高度表达，并参与核斑形成以及 mRNA 编辑和基因表达。因此，NEAT1 是治疗多种疾病的潜在生物标志物，这可能是由两个因素（NEAT1 的异构体和作为 ceRNA 的 NEAT1 海绵 miRNA）引起的。然而，NEAT1 的异常表达与各种疾病之间的机制和下游效应仍存在许多混淆。本综述总结了 NEAT1 在癌症和其他病理中的最新研究进展，为相关疾病的治疗提供了更可靠的理论基础。
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