Department of Urology, the First Hospital of Jilin University, Changchun 130021, Jilin, China.
Department of Urology, the First Hospital of Jilin University, Changchun 130021, Jilin, China.
Transpl Immunol. 2022 Dec;75:101718. doi: 10.1016/j.trim.2022.101718. Epub 2022 Sep 17.
Renal transplantation is currently the best treatment option for patients with end-stage kidney disease. Ischemia/reperfusion injury (IRI), which is an inevitable event during renal transplantation, has a profound impact on the function of transplanted kidneys. It has been well demonstrated that innate immune system plays an important role in the process of renal IRI. As a critical component of innate immune system, Nod-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome has received great attention from scientific community over the past decade. The main function of NLRP3 inflammasome is mediating activation of caspase-1 and maturation of interleukin (IL)-1β and IL-18. In this review, we summarize the associated molecular signaling events about NLRP3 inflammasome in renal IRI, and highlight the possibility of targeting NLRP3 inflammasome to minimize renal IRI during transplantation.
肾移植是目前治疗终末期肾病患者的最佳选择。缺血/再灌注损伤（IRI）是肾移植过程中不可避免的事件，它对移植肾的功能有深远的影响。已有研究证实，固有免疫系统在肾 IRI 过程中发挥着重要作用。作为固有免疫系统的关键组成部分，Nod 样受体家族含pyrin 结构域蛋白 3（NLRP3）炎性小体在过去十年中受到科学界的广泛关注。NLRP3 炎性小体的主要功能是介导半胱氨酸天冬氨酸蛋白酶-1（caspase-1）的激活以及白细胞介素（IL）-1β和 IL-18 的成熟。在本综述中，我们总结了 NLRP3 炎性小体在肾 IRI 中相关的分子信号事件，并强调了针对 NLRP3 炎性小体以最小化移植过程中肾 IRI 的可能性。
