• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

长链非编码RNA LINC01224通过调控miR-193a-5p/NUP210轴促进三阴性乳腺癌细胞的恶性行为。

Long Non-coding RNA LINC01224 Promotes the Malignant Behaviors of Triple Negative Breast Cancer Cells via Regulating the miR-193a-5p/NUP210 Axis.

作者信息

Sang Kai, Yi Tongbo, Pan Chi, Zhou Jian, Yu Lei

机构信息

Department of Breast Surgery, Jiangsu Taizhou People's Hospital, Taizhou, 225300, Jiangsu, China.

Department of Oncology, Jiangsu Taizhou People's Hospital, No.399 Hailing Road, Taizhou, 225300, Jiangsu, China.

出版信息

Mol Biotechnol. 2023 Apr;65(4):624-636. doi: 10.1007/s12033-022-00555-4. Epub 2022 Sep 20.

DOI:10.1007/s12033-022-00555-4
PMID:36127622
Abstract

Triple negative breast cancer (TNBC) is a prevalent malignant tumor in women and is characterized by high incidence and mortality. Current evidence has suggested that multiple long noncoding RNAs (lncRNAs) play regulatory roles in TNBC, while the specific mechanism of LINC01224 in TNBC remains unclear. In this study, LINC01224 was highly expressed in TNBC cells. Moreover, LINC01224 downregulation inhibited TNBC cell proliferation, migration, and invasion, and promoted cell apoptosis. Additionally, LINC01224 stabilized NUP210 mRNA through interaction with miR-193a-5p, thereby aggravating the malignant phenotypes of TNBC. Overall, LINC01224 functions as a tumor promoter for TNBC.

摘要

三阴性乳腺癌（TNBC）是女性中一种常见的恶性肿瘤，其特点是发病率和死亡率高。目前的证据表明，多种长链非编码RNA（lncRNAs）在TNBC中发挥调节作用，而LINC01224在TNBC中的具体机制仍不清楚。在本研究中，LINC01224在TNBC细胞中高表达。此外，LINC01224的下调抑制了TNBC细胞的增殖、迁移和侵袭，并促进了细胞凋亡。此外，LINC01224通过与miR-193a-5p相互作用稳定NUP210 mRNA，从而加重了TNBC的恶性表型。总体而言，LINC01224在TNBC中起肿瘤促进作用。

相似文献

1
Long Non-coding RNA LINC01224 Promotes the Malignant Behaviors of Triple Negative Breast Cancer Cells via Regulating the miR-193a-5p/NUP210 Axis.长链非编码RNA LINC01224通过调控miR-193a-5p/NUP210轴促进三阴性乳腺癌细胞的恶性行为。
Mol Biotechnol. 2023 Apr;65(4):624-636. doi: 10.1007/s12033-022-00555-4. Epub 2022 Sep 20.
2
LINC01224 facilitates the proliferation and inhibits the radiosensitivity of melanoma cells through the miR-193a-5p/NR1D2 axis.LINC01224 通过 miR-193a-5p/NR1D2 轴促进黑色素瘤细胞的增殖并抑制其放射敏感性。
Kaohsiung J Med Sci. 2022 Mar;38(3):196-206. doi: 10.1002/kjm2.12467. Epub 2021 Nov 15.
3
Long non-coding RNA SNHG8 enhances triple-negative breast cancer cell proliferation and migration by regulating the miR-335-5p/PYGO2 axis.长链非编码 RNA SNHG8 通过调控 miR-335-5p/PYGO2 轴促进三阴性乳腺癌细胞的增殖和迁移。
Biol Direct. 2021 Aug 6;16(1):13. doi: 10.1186/s13062-021-00295-6.
4
LINC01224 accelerates malignant transformation via MiR-193a-5p/CDK8 axis in gastric cancer.LINC01224 通过 miR-193a-5p/CDK8 轴促进胃癌的恶性转化。
Cancer Med. 2021 Feb;10(4):1377-1393. doi: 10.1002/cam4.3726.
5
LncRNA WEE2-AS1 promotes proliferation and inhibits apoptosis in triple negative breast cancer cells via regulating miR-32-5p/TOB1 axis.长链非编码 RNA WEE2-AS1 通过调控 miR-32-5p/TOB1 轴促进三阴性乳腺癌细胞的增殖并抑制凋亡。
Biochem Biophys Res Commun. 2020 Jun 11;526(4):1005-1012. doi: 10.1016/j.bbrc.2020.01.170. Epub 2020 Apr 16.
6
Long non-coding RNA linc00921 suppresses tumorigenesis and epithelial-to-mesenchymal transition of triple-negative breast cancer via targeting miR-9-5p/LZTS2 axis.长链非编码RNA linc00921通过靶向miR-9-5p/LZTS2轴抑制三阴性乳腺癌的肿瘤发生和上皮-间质转化。
Hum Cell. 2022 May;35(3):909-923. doi: 10.1007/s13577-022-00685-6. Epub 2022 Feb 18.
7
LncRNA FAM83H-AS1 promotes triple-negative breast cancer progression by regulating the miR-136-5p/metadherin axis.长链非编码 RNA FAM83H-AS1 通过调控 miR-136-5p/metadherin 轴促进三阴性乳腺癌的进展。
Aging (Albany NY). 2020 Feb 17;12(4):3594-3616. doi: 10.18632/aging.102832.
8
Long noncoding RNA GAS5 suppresses triple negative breast cancer progression through inhibition of proliferation and invasion by competitively binding miR-196a-5p.长链非编码 RNA GAS5 通过竞争性结合 miR-196a-5p 抑制增殖和侵袭来抑制三阴性乳腺癌的进展。
Biomed Pharmacother. 2018 Aug;104:451-457. doi: 10.1016/j.biopha.2018.05.056. Epub 2018 May 25.
9
Long non-coding RNA MALAT1 promotes proliferation and invasion via targeting miR-129-5p in triple-negative breast cancer.长链非编码 RNA MALAT1 通过靶向 miR-129-5p 促进三阴性乳腺癌的增殖和侵袭。
Biomed Pharmacother. 2017 Nov;95:922-928. doi: 10.1016/j.biopha.2017.09.005. Epub 2017 Sep 12.
10
LncRNA HCP5 promotes triple negative breast cancer progression as a ceRNA to regulate BIRC3 by sponging miR-219a-5p.长链非编码 RNA HCP5 通过海绵吸附 miR-219a-5p 调控 BIRC3 促进三阴性乳腺癌进展。
Cancer Med. 2019 Aug;8(9):4389-4403. doi: 10.1002/cam4.2335. Epub 2019 Jun 18.

引用本文的文献

1
LINC01224 promotes the Warburg effect in gastric cancer by activating the miR-486-5p/PI3K axis.LINC01224通过激活miR-486-5p/PI3K轴促进胃癌的瓦伯格效应。
In Vitro Cell Dev Biol Anim. 2025 Feb;61(2):228-244. doi: 10.1007/s11626-024-01001-2. Epub 2025 Jan 28.
2
Transcriptomic-Based Identification of miR-125a Novel Targets in Human Hepatocarcinoma Cells.基于转录组学鉴定人肝癌细胞中miR-125a的新靶点
Biomolecules. 2025 Jan 18;15(1):144. doi: 10.3390/biom15010144.
3
Four differentially expressed exosomal miRNAs as prognostic biomarkers and therapy targets in endometrial cancer: Bioinformatic analysis.

本文引用的文献

1
Potential Predictive and Prognostic Value of Biomarkers Related to Immune Checkpoint Inhibitor Therapy of Triple-Negative Breast Cancer.与三阴性乳腺癌免疫检查点抑制剂治疗相关生物标志物的潜在预测和预后价值
Front Oncol. 2022 Apr 29;12:779786. doi: 10.3389/fonc.2022.779786. eCollection 2022.
2
Cross-Platform in-silico Analyses Exploring Tumor Immune Microenvironment with Prognostic Value in Triple-Negative Breast Cancer.探索三阴性乳腺癌中具有预后价值的肿瘤免疫微环境的跨平台计算机模拟分析
Breast Cancer (Dove Med Press). 2022 Apr 12;14:85-99. doi: 10.2147/BCTT.S359346. eCollection 2022.
3
Cancer statistics, 2022.
四种差异表达的外泌体 miRNA 作为子宫内膜癌的预后生物标志物和治疗靶点：生物信息学分析。
Medicine (Baltimore). 2023 Aug 25;102(34):e34998. doi: 10.1097/MD.0000000000034998.
4
Exploiting Long Non-Coding RNAs and Circular RNAs as Pharmacological Targets in Triple-Negative Breast Cancer Treatment.将长链非编码RNA和环状RNA作为三阴性乳腺癌治疗的药理学靶点
Cancers (Basel). 2023 Aug 20;15(16):4181. doi: 10.3390/cancers15164181.
癌症统计数据，2022 年。
CA Cancer J Clin. 2022 Jan;72(1):7-33. doi: 10.3322/caac.21708. Epub 2022 Jan 12.
4
Nuclear pore protein NUP210 depletion suppresses metastasis through heterochromatin-mediated disruption of tumor cell mechanical response.核孔蛋白 NUP210 的耗竭通过异染色质介导的肿瘤细胞机械反应破坏来抑制转移。
Nat Commun. 2021 Dec 13;12(1):7216. doi: 10.1038/s41467-021-27451-w.
5
LINC01224 facilitates the proliferation and inhibits the radiosensitivity of melanoma cells through the miR-193a-5p/NR1D2 axis.LINC01224 通过 miR-193a-5p/NR1D2 轴促进黑色素瘤细胞的增殖并抑制其放射敏感性。
Kaohsiung J Med Sci. 2022 Mar;38(3):196-206. doi: 10.1002/kjm2.12467. Epub 2021 Nov 15.
6
LINC01224 accelerates malignant transformation via MiR-193a-5p/CDK8 axis in gastric cancer.LINC01224 通过 miR-193a-5p/CDK8 轴促进胃癌的恶性转化。
Cancer Med. 2021 Feb;10(4):1377-1393. doi: 10.1002/cam4.3726.
7
LncRNA ZFAS1 inhibits triple-negative breast cancer by targeting STAT3.长链非编码 RNA ZFAS1 通过靶向 STAT3 抑制三阴性乳腺癌。
Biochimie. 2021 Mar;182:99-107. doi: 10.1016/j.biochi.2020.12.026. Epub 2021 Jan 9.
8
Practical classification of triple-negative breast cancer: intratumoral heterogeneity, mechanisms of drug resistance, and novel therapies.三阴性乳腺癌的实用分类：瘤内异质性、耐药机制及新疗法
NPJ Breast Cancer. 2020 Oct 16;6:54. doi: 10.1038/s41523-020-00197-2. eCollection 2020.
9
lncRNA LCPAT1 Upregulation Promotes Breast Cancer Progression via Enhancing MFAP2 Transcription.长链非编码RNA LCPAT1上调通过增强MFAP2转录促进乳腺癌进展。
Mol Ther Nucleic Acids. 2020 Sep 4;21:804-813. doi: 10.1016/j.omtn.2020.07.015. Epub 2020 Jul 10.
10
Long Non-Coding RNA MNX1-AS1 Promotes Progression of Triple Negative Breast Cancer by Enhancing Phosphorylation of Stat3.长链非编码RNA MNX1-AS1通过增强Stat3磷酸化促进三阴性乳腺癌进展。
Front Oncol. 2020 Jul 10;10:1108. doi: 10.3389/fonc.2020.01108. eCollection 2020.