• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

失调的环状 RNA 与多发性骨髓瘤的预后密切相关，circ_0026652 通过 microRNA-608 介导的 Wnt/β-catenin 通路预测硼替佐米为基础的治疗反应和生存。

Dysregulated circular RNAs are closely linked to multiple myeloma prognosis, with circ_0026652 predicting bortezomib‑based treatment response and survival via the microRNA‑608‑mediated Wnt/β‑catenin pathway.

机构信息

Department of Hematology, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai 200081, P.R. China.

Department of Hematology, Changzheng Hospital, Second Military Medical University, Shanghai 200003, P.R. China.

出版信息

Oncol Rep. 2022 Nov;48(5). doi: 10.3892/or.2022.8410. Epub 2022 Sep 21.

DOI:10.3892/or.2022.8410
PMID:36129153
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9535628/
Abstract

Circular RNA (circRNA/circ) profiles have been suggested to be involved in the prognosis of several types of solid tumors and hematological malignancies, including multiple myeloma (MM). Therefore, the aim of the present study was to comprehensively explore the involvement of circRNA profiles in MM prognosis. A total of 60 patients with MM that underwent bortezomib‑based induction therapy were enrolled. Next, eight patients with complete response (CR) and eight with no response (NR) were randomly selected to detect their circRNA profiles in bone marrow plasma cells (BMPCs) by microarray. Next, 10 candidate circRNAs were verified via reverse transcription‑quantitative PCR (RT‑qPCR) in the BMPCs of 60 patients with MM. Finally, the molecular mechanism of circ_0026652 knockdown underlying the regulation of chemosensitivity to bortezomib was assessed. Microarray showed that 79 circRNAs were upregulated and 167 were downregulated in CR compared with NR cases, which were found to be enriched in carcinogenic and chemoresistance‑related pathways (Wnt, mTOR and MAPK pathways). RT‑qPCR showed that 8/10 circRNAs (circ_0026652, circ_0068708, circ_0088128, circ_0001566, circ_0031113, circ_0083587, circ_0005552 and circ_0007171) were associated with treatment response [CR or objective response rate (ORR)] and 5/10 circRNAs (circ_0026652, circ_0068708, circ_0001566, circ_0031113 and circ_0005552) were associated with progression‑free survival (PFS) or overall survival (OS). Of note, circ_0026652 was a key prognostic marker simultaneously associated with CR, ORR, PFS and OS. Cellular experiments showed that circ_0026652 knockdown enhanced chemosensitivity to bortezomib through the microRNA (miR)‑608‑mediated Wnt/β‑catenin pathway in U266 and RPIM‑8226 cells. In conclusion, dysregulated circRNA profiles were closely associated with MM prognosis, with circ_0026652 being linked to bortezomib‑based treatment response and survival through the miR‑608‑mediated Wnt/β‑catenin pathway.

摘要

环状 RNA (circRNA/circ) 谱已被证明参与多种实体瘤和血液恶性肿瘤的预后，包括多发性骨髓瘤 (MM)。因此，本研究的目的是全面探讨 circRNA 谱在 MM 预后中的作用。共纳入 60 例接受硼替佐米为基础的诱导治疗的 MM 患者。然后，随机选择 8 例完全缓解 (CR) 和 8 例无反应 (NR) 的患者，通过微阵列检测其骨髓浆细胞 (BMPC) 中的 circRNA 谱。接下来，通过逆转录-定量 PCR (RT-qPCR) 在 60 例 MM 患者的 BMPC 中验证了 10 个候选 circRNA。最后，评估了 circ_0026652 敲低对硼替佐米化疗敏感性的调节作用。微阵列显示，与 NR 相比，CR 病例中 79 个 circRNA 上调，167 个 circRNA 下调，这些 circRNA 被富集到致癌和化疗耐药相关通路 (Wnt、mTOR 和 MAPK 通路)。RT-qPCR 显示，10 个 circRNA 中的 8 个 (circ_0026652、circ_0068708、circ_0088128、circ_0001566、circ_0031113、circ_0083587、circ_0005552 和 circ_0007171) 与治疗反应 (CR 或客观缓解率 [ORR]) 相关，而 10 个 circRNA 中的 5 个 (circ_0026652、circ_0068708、circ_0001566、circ_0031113 和 circ_0005552) 与无进展生存期 (PFS) 或总生存期 (OS) 相关。值得注意的是，circ_0026652 是一个与 CR、ORR、PFS 和 OS 同时相关的关键预后标志物。细胞实验表明，circ_0026652 通过 U266 和 RPIM-8226 细胞中的 microRNA (miR)-608 介导的 Wnt/β-catenin 通路降低了对硼替佐米的化疗敏感性。总之，失调的 circRNA 谱与 MM 的预后密切相关，circ_0026652 通过 miR-608 介导的 Wnt/β-catenin 通路与硼替佐米为基础的治疗反应和生存相关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee67/9535628/b1fcfea3eb45/or-48-05-08410-g10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee67/9535628/26df8a959e38/or-48-05-08410-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee67/9535628/bf166385e65a/or-48-05-08410-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee67/9535628/8d61e2b820a5/or-48-05-08410-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee67/9535628/1c896e46e718/or-48-05-08410-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee67/9535628/1f9b51ca8bfb/or-48-05-08410-g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee67/9535628/cc41f29ee5bf/or-48-05-08410-g05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee67/9535628/7e07e8f24850/or-48-05-08410-g06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee67/9535628/d6fe01c2e191/or-48-05-08410-g07.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee67/9535628/7db7b687128d/or-48-05-08410-g08.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee67/9535628/a7598c008c98/or-48-05-08410-g09.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee67/9535628/b1fcfea3eb45/or-48-05-08410-g10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee67/9535628/26df8a959e38/or-48-05-08410-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee67/9535628/bf166385e65a/or-48-05-08410-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee67/9535628/8d61e2b820a5/or-48-05-08410-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee67/9535628/1c896e46e718/or-48-05-08410-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee67/9535628/1f9b51ca8bfb/or-48-05-08410-g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee67/9535628/cc41f29ee5bf/or-48-05-08410-g05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee67/9535628/7e07e8f24850/or-48-05-08410-g06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee67/9535628/d6fe01c2e191/or-48-05-08410-g07.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee67/9535628/7db7b687128d/or-48-05-08410-g08.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee67/9535628/a7598c008c98/or-48-05-08410-g09.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee67/9535628/b1fcfea3eb45/or-48-05-08410-g10.jpg

相似文献

1
Dysregulated circular RNAs are closely linked to multiple myeloma prognosis, with circ_0026652 predicting bortezomib‑based treatment response and survival via the microRNA‑608‑mediated Wnt/β‑catenin pathway.失调的环状 RNA 与多发性骨髓瘤的预后密切相关，circ_0026652 通过 microRNA-608 介导的 Wnt/β-catenin 通路预测硼替佐米为基础的治疗反应和生存。
Oncol Rep. 2022 Nov;48(5). doi: 10.3892/or.2022.8410. Epub 2022 Sep 21.
2
Circular RNA_0000190 and its target microRNA-767-5p are dysregulated, and they are related to risk stratification as well as prognosis in multiple myeloma patients.环状 RNA_0000190 及其靶 microRNA-767-5p 失调，与多发性骨髓瘤患者的风险分层及预后相关。
Ir J Med Sci. 2022 Apr;191(2):671-679. doi: 10.1007/s11845-021-02586-3. Epub 2021 Apr 16.
3
Integrative network analysis of circular RNAs reveals regulatory mechanisms for hepatic specification of human iPSC-derived endoderm.环状 RNA 的综合网络分析揭示了人诱导多能干细胞衍生内胚层肝脏特化的调控机制。
Stem Cell Res Ther. 2022 Sep 8;13(1):468. doi: 10.1186/s13287-022-03160-z.
4
Circular RNA_0003489 reflects unfavorable treatment response and shortened survival in newly diagnosed multiple myeloma patients who receive bortezomib-based induction therapy.环状 RNA_0003489 反映了接受硼替佐米为基础的诱导治疗的新诊断多发性骨髓瘤患者的不良治疗反应和生存时间缩短。
Hematology. 2024 Dec;29(1):2399419. doi: 10.1080/16078454.2024.2399419. Epub 2024 Sep 13.
5
Comprehensive profiling of circular RNA expressions reveals potential diagnostic and prognostic biomarkers in multiple myeloma.环状 RNA 表达谱的综合分析揭示了多发性骨髓瘤潜在的诊断和预后生物标志物。
BMC Cancer. 2020 Jan 16;20(1):40. doi: 10.1186/s12885-020-6515-2.
6
Depletion of circ_0007841 inhibits multiple myeloma development and BTZ resistance via miR-129-5p/JAG1 axis.环状 RNA 0007841 通过 miR-129-5p/JAG1 轴抑制多发性骨髓瘤的发展和硼替佐米耐药性。
Cell Cycle. 2020 Dec;19(23):3289-3302. doi: 10.1080/15384101.2020.1839701. Epub 2020 Nov 1.
7
Circular RNA MAPK4 (circ-MAPK4) inhibits cell apoptosis via MAPK signaling pathway by sponging miR-125a-3p in gliomas.环状 RNA MAPK4（circ-MAPK4）通过海绵吸附 miR-125a-3p 抑制 MAPK 信号通路从而抑制神经胶质瘤细胞凋亡。
Mol Cancer. 2020 Jan 28;19(1):17. doi: 10.1186/s12943-019-1120-1.
8
Comprehensive circular RNA profiling reveals the regulatory role of the hsa_circ_0137606/miR‑1231 pathway in bladder cancer progression.全面环状 RNA 谱分析揭示 hsa_circ_0137606/miR-1231 通路在膀胱癌进展中的调控作用。
Int J Mol Med. 2019 Nov;44(5):1719-1728. doi: 10.3892/ijmm.2019.4340. Epub 2019 Sep 17.
9
Screening and validating circular RNAs that estimate disease risk and treatment response of pediatric acute myeloid leukemia: a microarray-based analyses and RT-qPCR validation.基于芯片分析和 RT-qPCR 验证的儿童急性髓系白血病疾病风险和治疗反应预测的环状 RNA 筛选和验证。
J Cancer Res Clin Oncol. 2023 Oct;149(13):11233-11245. doi: 10.1007/s00432-023-04879-9. Epub 2023 Jun 26.
10
Downregulated hsa_circ_0077837 and hsa_circ_0004826, facilitate bladder cancer progression and predict poor prognosis for bladder cancer patients.下调的hsa_circ_0077837和hsa_circ_0004826促进膀胱癌进展，并预测膀胱癌患者预后不良。
Cancer Med. 2020 Jun;9(11):3885-3903. doi: 10.1002/cam4.3006. Epub 2020 Apr 6.

引用本文的文献

1
Recent Progress of CircRNAs in Hematological Malignancies.环状 RNA 在血液系统恶性肿瘤中的最新研究进展。
Int J Med Sci. 2024 Sep 30;21(13):2544-2561. doi: 10.7150/ijms.98156. eCollection 2024.
2
Combination of multiple omics techniques for a personalized therapy or treatment selection.多种组学技术的联合应用，以实现个性化治疗或治疗选择。
Front Immunol. 2023 Sep 27;14:1258013. doi: 10.3389/fimmu.2023.1258013. eCollection 2023.

本文引用的文献

1
[Guidelines for the diagnosis and management of multiple myeloma in China (2022 revision)].中国多发性骨髓瘤诊断与治疗指南（2022年修订版）
Zhonghua Nei Ke Za Zhi. 2022 May 1;61(5):480-487. doi: 10.3760/cma.j.cn112138-20220309-00165.
2
Identification of hub genes in bladder cancer based on weighted gene co-expression network analysis from TCGA database.基于 TCGA 数据库的加权基因共表达网络分析鉴定膀胱癌的枢纽基因。
Cancer Rep (Hoboken). 2022 Sep;5(9):e1557. doi: 10.1002/cnr2.1557. Epub 2021 Sep 20.
3
Circular RNA_0001946 is insufficiently expressed in tumor tissues, while its higher expression correlates with less lymph node metastasis, lower TNM stage, and improved prognosis in NSCLC patients.
Circular RNA_0001946 在肿瘤组织中表达不足，而其高表达与 NSCLC 患者淋巴结转移较少、TNM 分期较低和预后改善相关。
J Clin Lab Anal. 2021 Aug;35(8):e23625. doi: 10.1002/jcla.23625. Epub 2021 Jul 3.
4
WNT Signaling in Melanoma.WNT 信号通路在黑色素瘤中的作用
Int J Mol Sci. 2020 Jul 9;21(14):4852. doi: 10.3390/ijms21144852.
5
Circular RNA profile of acute myeloid leukaemia indicates circular RNA annexin A2 as a potential biomarker and therapeutic target for acute myeloid leukaemia.急性髓系白血病的环状RNA谱表明环状RNA膜联蛋白A2是急性髓系白血病的潜在生物标志物和治疗靶点。
Am J Transl Res. 2020 May 15;12(5):1683-1699. eCollection 2020.
6
Discovery of Peptide Boronate Derivatives as Histone Deacetylase and Proteasome Dual Inhibitors for Overcoming Bortezomib Resistance of Multiple Myeloma.发现肽硼酸衍生物作为组蛋白去乙酰化酶和蛋白酶体双重抑制剂，用于克服多发性骨髓瘤对硼替佐米的耐药性。
J Med Chem. 2020 May 14;63(9):4701-4715. doi: 10.1021/acs.jmedchem.9b02161. Epub 2020 Apr 23.
7
hsa_circRNA_101237: A Novel Diagnostic and Prognostic Biomarker and Potential Therapeutic Target for Multiple Myeloma.人源环状RNA_101237：一种用于多发性骨髓瘤的新型诊断和预后生物标志物及潜在治疗靶点
Cancer Manag Res. 2020 Mar 20;12:2109-2118. doi: 10.2147/CMAR.S241089. eCollection 2020.
8
Multiple Myeloma: Available Therapies and Causes of Drug Resistance.多发性骨髓瘤：现有治疗方法及耐药原因
Cancers (Basel). 2020 Feb 10;12(2):407. doi: 10.3390/cancers12020407.
9
Comprehensive profiling of circular RNA expressions reveals potential diagnostic and prognostic biomarkers in multiple myeloma.环状 RNA 表达谱的综合分析揭示了多发性骨髓瘤潜在的诊断和预后生物标志物。
BMC Cancer. 2020 Jan 16;20(1):40. doi: 10.1186/s12885-020-6515-2.
10
LncRNA XIST serves as a ceRNA to regulate the expression of ASF1A, BRWD1M, and PFKFB2 in kidney transplant acute kidney injury via sponging hsa-miR-212-3p and hsa-miR-122-5p.LncRNA XIST 通过海绵吸附 hsa-miR-212-3p 和 hsa-miR-122-5p 作为 ceRNA 调节肾移植急性肾损伤中 ASF1A、BRWD1M 和 PFKFB2 的表达。
Cell Cycle. 2020 Feb;19(3):290-299. doi: 10.1080/15384101.2019.1707454. Epub 2020 Jan 8.