Sakanashi M, Takeo S, Nakasone J, Nagamine F, Miyamoto Y, Kato T
Jpn J Pharmacol. 1987 Apr;43(4):465-8. doi: 10.1254/jjp.43.465.
The depressant effect of indomethacin on contractions of isolated rat hearts was investigated under a constant heart rate. Ca2+ produced dose-dependent increases in myocardial contractile force and coronary perfusion pressure. Indomethacin-infusion significantly decreased myocardial contractile force and depressed increases in myocardial contractile force by Ca2+, but never affected both coronary perfusion pressure and increases in coronary perfusion pressure by Ca2+. Results suggest that indomethacin will depress myocardial contractile force with no involvement of any calcium antagonism.
在恒定心率条件下，研究了吲哚美辛对离体大鼠心脏收缩的抑制作用。钙离子使心肌收缩力和冠状动脉灌注压呈剂量依赖性增加。输注吲哚美辛显著降低心肌收缩力，并抑制钙离子引起的心肌收缩力增加，但对冠状动脉灌注压以及钙离子引起的冠状动脉灌注压升高均无影响。结果表明，吲哚美辛可抑制心肌收缩力，且不涉及任何钙拮抗作用。
