Sakanashi M, Takeo S, Kato T, Noguchi K, Nakasone J, Aniya Y
Toxicon. 1986;24(10):1019-22. doi: 10.1016/0041-0101(86)90009-7.
Crude habu venom decreased coronary perfusion pressure and produced a small increase in myocardial tension of isolated and perfused rat hearts. Indomethacin infusion depressed the fall in perfusion pressure caused by the venom, without affecting the increase in tension. Heated venom decreased perfusion pressure, but did not increase myocardial tension. These results suggest that crude habu venom has coronary vasodilating and positive inotropic effects, possibly through actions of a phospholipase A2 and a heat-labile component, respectively.
粗制的蝮蛇毒降低了离体灌注大鼠心脏的冠状动脉灌注压，并使心肌张力略有增加。输注吲哚美辛可抑制毒液引起的灌注压下降，但不影响张力的增加。加热后的毒液降低了灌注压，但未增加心肌张力。这些结果表明，粗制蝮蛇毒具有冠状动脉舒张和正性肌力作用，可能分别通过磷脂酶A2和一种热不稳定成分的作用来实现。
