聚四氟乙烯-氧化铝杂化纳米线减少血栓形成和生物污垢。

PTFEP-AlO hybrid nanowires reducing thrombosis and biofouling.

作者信息

Haidar Ayman, Ali Awadelkareem A, Veziroglu Salih, Fiutowski Jacek, Eichler Hermann, Müller Isabelle, Kiefer Karin, Faupel Franz, Bischoff Markus, Veith Michael, Aktas Oral Cenk, Abdul-Khaliq Hashim

机构信息

Department of Paediatric Cardiology, Saarland University Building 9 66421 Homburg Germany

Chair for Multicomponent Materials, Institute for Materials Science, Faculty of Engineering, Christian-Albrechts-University of Kiel Kaiserstr. 2 24143 Kiel Germany

出版信息

Nanoscale Adv. 2019 Oct 24;1(12):4659-4664. doi: 10.1039/c9na00436j. eCollection 2019 Dec 3.

DOI:10.1039/c9na00436j

PMID:36133130

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9419761/

Abstract

Thrombosis and bacterial infection are major problems in cardiovascular implants. Here we demonstrated that a superhydrophobic surface composed of poly(bis(2,2,2-trifluoroethoxy)phosphazene) (PTFEP)-AlO hybrid nanowires (NWs) is effective to reduce both platelet adhesion/activation and bacterial adherence/colonization. The proposed approach allows surface modification of cardiovascular implants which have 3D complex geometries.

摘要

血栓形成和细菌感染是心血管植入物中的主要问题。在此我们证明，由聚（双（2,2,2 - 三氟乙氧基）磷腈）（PTFEP）-AlO混合纳米线（NWs）组成的超疏水表面可有效减少血小板粘附/活化以及细菌粘附/定植。所提出的方法允许对具有三维复杂几何形状的心血管植入物进行表面改性。