van Herick R, Aronow W S
Clin Pharmacol Ther. 1978 Dec;24(6):678-82. doi: 10.1002/cpt1978246678.
Twenty patients with coronary heart disease participated in a double-blind, randomized, crossover study on three study mornings to evaluate the effect of oral oxprenolol 80 mg, oral propranolol 80 mg, and placebo on left ventricular contractility. Systolic time intervals were performed in the control period and at 60, 90, 120, 150, 180, 240, 300, and 360 min after medication. None of 20 patients developed adverse effects. The 80-mg doses of oxprenolol and propranolol had a negative chronotropic effect, with the resting heart rate slightly but consistently decreased more after propranolol, attaining statistical significance at 90, 150, and 300 min. That the 80-mg doses of oral oxprenolol and propranolol also induced a negative inotropic effect was indicated by a similar prolongation of the external isovolumic contraction time and pre-ejection period intervals. This equipotent dose of oxprenolol in producing a negative inotropic effect induces less resting bradycardia than propranolol.
20名冠心病患者在三个研究日上午参与了一项双盲、随机、交叉研究，以评估口服80毫克氧烯洛尔、口服80毫克普萘洛尔和安慰剂对左心室收缩力的影响。在对照期以及用药后60、90、120、150、180、240、300和360分钟进行收缩期时间间期测定。20名患者均未出现不良反应。80毫克剂量的氧烯洛尔和普萘洛尔具有负性变时作用，静息心率在普萘洛尔用药后略有但持续下降更多，在90、150和300分钟时达到统计学显著性。口服80毫克剂量的氧烯洛尔和普萘洛尔也诱导了负性变力作用，这表现为体外等容收缩时间和射血前期间期的类似延长。产生负性变力作用的等效剂量氧烯洛尔比普萘洛尔引起的静息心动过缓更少。
