普萘洛尔、美托洛尔和氧烯洛尔作用于正常受试者后对高碳酸血症的通气反应。

Ventilatory response to hypercapnia in normal subjects after propranolol, metoprolol and oxprenolol.

作者信息

Folgering H, Braakhekke J

出版信息

Respiration. 1980;39(3):139-43. doi: 10.1159/000194208.

DOI:10.1159/000194208

Abstract

Steady state ventilatory response curves to CO2 were taken in 8 normal subjects in control situations and taking clinical doses of propranolol, oxprenolol and metoprolol in a double-blind crossover design. Furthermore, the expiratory peak flow was measured. No effect was found of any of the beta-blockers on the resting ventilatory parameters, the sensitivity to CO2 or the peak flow values.

摘要

在8名正常受试者处于对照情况以及采用双盲交叉设计服用临床剂量的普萘洛尔、氧烯洛尔和美托洛尔时，测定了对二氧化碳的稳态通气反应曲线。此外，还测量了呼气峰值流速。未发现任何一种β受体阻滞剂对静息通气参数、对二氧化碳的敏感性或峰值流速值有影响。