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聚合物载体在药物递送中对自噬发生发展的影响。

Effects of polymer carriers on the occurrence and development of autophagy in drug delivery.

作者信息

Wang Changduo, Li Yang, Tian Yu, Ma Wenyuan, Sun Yong

机构信息

Department of Pharmaceutics, School of Pharmacy, Qingdao University Qingdao 266000 China

Department of Pharmacy, Qingdao Municipal Hospital Qingdao 266000 China.

出版信息

Nanoscale Adv. 2022 Jul 20;4(18):3676-3688. doi: 10.1039/d2na00355d. eCollection 2022 Sep 13.

DOI:10.1039/d2na00355d
PMID:36133340
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9470016/
Abstract

Autophagy is an evolutionarily conserved catabolic process that can degrade cytoplasmic materials and recycle energy to maintain metabolite homeostasis in cells. Autophagy is closely related to various physiological or pathological processes. Macromolecular materials are widely used in drug delivery systems and disease treatments due to their intrinsic effects, such as altered pharmacokinetics and biodistribution. Interaction of autophagic flux or the signal pathway with macromolecules may cause autophagy inhibition or autophagy cell death. This review covers autophagy regulation pathways and macromolecular materials (including functional micelles, biodegradable and pH-sensitive polymers, biomacromolecules, dendrimers, coordination polymers, and hybrid nanoparticles) mediated autophagy modulation.

摘要

自噬是一种进化上保守的分解代谢过程，它可以降解细胞质物质并回收能量，以维持细胞内代谢物的稳态。自噬与各种生理或病理过程密切相关。大分子材料因其内在作用，如改变药代动力学和生物分布，而被广泛应用于药物递送系统和疾病治疗。自噬通量或信号通路与大分子的相互作用可能导致自噬抑制或自噬性细胞死亡。本文综述了自噬调控途径以及大分子材料（包括功能性胶束、可生物降解和pH敏感聚合物、生物大分子、树枝状大分子、配位聚合物和杂化纳米颗粒）介导的自噬调节。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/811e/9470016/973a5143cd4e/d2na00355d-f8.jpg
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