Stefaniu Cristina, Wölk Christian, Brezesinski Gerald, Schneck Emanuel
Departments of Biomaterials and Biomolecular Systems, Max Planck Institute of Colloids and Interfaces Am Mühlenberg 1 14476 Potsdam Germany
Institute of Pharmacy, Research Group Biochemical Pharmacy, Martin-Luther-University Wolfgang-Langenbeck-Strasse 4 06120 Halle (Saale) Germany.
Nanoscale Adv. 2019 Jul 23;1(9):3529-3536. doi: 10.1039/c9na00355j. eCollection 2019 Sep 11.
Artificial cationic lipids are already recognized as highly efficient gene therapy tools. Here, we focus on another potential use of aminolipids, in their electrically-uncharged state, for the formation of covalently cross-linked, one-molecule-thin films at interfaces. Such films are envisioned for future (bio-)materials applications. To this end, Langmuir monolayers of structurally different aminolipids are comprehensively characterized with the help of highly sensitive surface characterization techniques. Pressure-area isotherms, Brewster angle microscopy, grazing-incidence X-ray diffraction and infrared reflection-absorption spectrometry experiments provide a detailed, comparative molecular picture of the formed monolayers. This physico-chemical study highlights the relationship between chemical structures and intermolecular interactions, which can serve as a basis for the rational design of cross-linked thin films with precisely controlled properties.
人工阳离子脂质已被公认为是高效的基因治疗工具。在此，我们关注氨基脂质在其电中性状态下的另一种潜在用途，即用于在界面处形成共价交联的单分子薄膜。此类薄膜有望用于未来的（生物）材料应用。为此，借助高灵敏度表面表征技术对结构不同的氨基脂质的朗缪尔单分子层进行了全面表征。压力-面积等温线、布儒斯特角显微镜、掠入射X射线衍射和红外反射吸收光谱实验提供了所形成单分子层详细的、对比性的分子图像。这项物理化学研究突出了化学结构与分子间相互作用之间的关系，这可为合理设计具有精确可控性质的交联薄膜奠定基础。
