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人工二尖瓣血栓形成:二尖瓣手术和冠状动脉旁路移植术后的一种并发症。

Prosthetic Mitral Valve Thrombosis: A Complication Following Mitral Valve Surgery and Coronary Artery Bypass Graft Surgery.

作者信息

Mirza Jacqueline, Trenschel Robert W, Davenport James

机构信息

Medical School, Dr. Kiran C. Patel College of Allopathic Medicine, Nova Southeastern University, Davie, USA.

Cardiology, Kendall Regional Medical Center, Kendall, USA.

出版信息

Cureus. 2022 Aug 14;14(8):e28013. doi: 10.7759/cureus.28013. eCollection 2022 Aug.

DOI:10.7759/cureus.28013
PMID:36134064
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9470538/
Abstract

Mitral valve regurgitation is a common valvular defect that can lead to severe complications, requiring surgical intervention, often in the form of either mitral valve repair or replacement. This case report follows a 63-year-old male with multivessel coronary artery disease, who initially presented to the emergency department (ED) with a non-ST elevation myocardial infarction (NSTEMI) secondary to multivessel coronary artery disease with severe mitral regurgitation, and subsequently underwent coronary artery bypass grafting (CABG) with repair of the mitral valve. He was readmitted a month later with endocarditis of the mitral valve and underwent a reoperation with a bioprosthetic mitral valve replacement and massive reconstruction of the right ventricle, after which he failed to recover postoperatively. A repeat transesophageal echocardiogram (TEE) during his final chest washout procedure revealed echodensities suspicious for thrombi and, despite the team's best efforts, the patient expired. This report demonstrates that even with appropriate medical decision-making, poor outcomes still result, especially in patients with comorbidities including multivessel disease, respiratory illness, and endocarditis. This study suggests that continuing to characterize repairs or replacements of the mitral valve is essential. Additionally, aggressive and newly emerging procedures, such as percutaneous approaches to mitral valve repair or replacement, may be considered for use to mitigate negative outcomes, especially with an aging population.

摘要

二尖瓣反流是一种常见的瓣膜缺陷,可导致严重并发症,常需手术干预,通常采用二尖瓣修复或置换的形式。本病例报告追踪了一名患有多支冠状动脉疾病的63岁男性,他最初因多支冠状动脉疾病继发严重二尖瓣反流导致非ST段抬高型心肌梗死(NSTEMI)而就诊于急诊科(ED),随后接受了冠状动脉旁路移植术(CABG)并修复了二尖瓣。一个月后,他因二尖瓣心内膜炎再次入院,接受了生物人工二尖瓣置换和右心室大规模重建的再次手术,术后未能康复。在他最后一次胸部冲洗手术期间进行的重复经食管超声心动图(TEE)显示有可疑血栓的回声密度,尽管团队尽了最大努力,患者仍死亡。本报告表明,即使做出了适当的医疗决策,仍会出现不良后果,尤其是在患有多支血管疾病、呼吸系统疾病和心内膜炎等合并症的患者中。这项研究表明,继续对二尖瓣的修复或置换进行特征描述至关重要。此外,对于老龄化人群,可能考虑采用积极的和新出现的手术方法,如经皮二尖瓣修复或置换方法,以减轻不良后果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa89/9470538/3bc0685f9740/cureus-0014-00000028013-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa89/9470538/0f170fdffecf/cureus-0014-00000028013-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa89/9470538/44a61863d414/cureus-0014-00000028013-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa89/9470538/d669376c1f81/cureus-0014-00000028013-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa89/9470538/3bc0685f9740/cureus-0014-00000028013-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa89/9470538/0f170fdffecf/cureus-0014-00000028013-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa89/9470538/44a61863d414/cureus-0014-00000028013-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa89/9470538/d669376c1f81/cureus-0014-00000028013-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa89/9470538/3bc0685f9740/cureus-0014-00000028013-i04.jpg

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本文引用的文献

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2020 ACC/AHA Guideline for the Management of Patients With Valvular Heart Disease: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines.2020美国心脏病学会/美国心脏协会瓣膜性心脏病患者管理指南:美国心脏病学会/美国心脏协会临床实践指南联合委员会报告
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MitraClip step by step; how to simplify the procedure.二尖瓣夹合术分步指南;如何简化手术过程。
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Ann Thorac Surg. 2014 Nov;98(5):1544-50. doi: 10.1016/j.athoracsur.2014.07.040. Epub 2014 Sep 22.
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Surgical revascularization is associated with maximal survival in patients with ischemic mitral regurgitation: a 20-year experience.手术血运重建与缺血性二尖瓣反流患者的最大生存率相关:20年经验。
Circulation. 2014 Jun 17;129(24):2547-56. doi: 10.1161/CIRCULATIONAHA.113.005223. Epub 2014 Apr 17.
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Re-repair of the mitral valve as a primary strategy for early and late failures of mitral valve repair.二尖瓣再次修复作为二尖瓣修复早期和晚期失败的主要策略。
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