Liu Fang, Qu Rongfeng, Yang Limin, Shi Guang, Hao Shuhong, Hu Chunmei
Department of Hematology and Oncology, The Second Hospital of Jilin University, Changchun, Jilin, People's Republic of China.
Onco Targets Ther. 2022 Sep 15;15:993-1009. doi: 10.2147/OTT.S371629. eCollection 2022.
Circular RNAs (circRNAs) participate in the occurrence and development of various diseases through different mechanisms, such as by acting as a microRNA (miRNA) sponge, interacting with RNA-binding proteins, and regulating gene transcription and protein translation. For example, the abnormal expression of specific circRNAs in tumor cells can alter key regulatory factors and the cell cycle network, resulting in cell cycle disorders and the development and metastasis of tumors. Here, we summarize the mechanisms involved in the circRNA-mediated processes that lead to uncontrolled cell cycle and tumor cell proliferation. Extensive studies investigating the abnormal expression of circRNAs in different cancer types have been conducted. The unique characteristics of circRNAs and their ability to regulate the cell cycle through diverse mechanisms is extremely valuable in tumor diagnosis, treatment, and prognosis. Our review may assist in further understanding the circRNA-mediated regulation of the cell cycle in tumors and provide insights for research on circRNA-based therapeutic strategies and biological diagnosis for cancer.
环状RNA（circRNAs）通过不同机制参与各种疾病的发生和发展，例如充当微小RNA（miRNA）海绵、与RNA结合蛋白相互作用以及调节基因转录和蛋白质翻译。例如，肿瘤细胞中特定circRNAs的异常表达可改变关键调节因子和细胞周期网络，导致细胞周期紊乱以及肿瘤的发生和转移。在此，我们总结了circRNA介导的导致细胞周期失控和肿瘤细胞增殖过程中涉及的机制。已经开展了大量研究来调查不同癌症类型中circRNAs的异常表达。circRNAs的独特特征及其通过多种机制调节细胞周期的能力在肿瘤诊断、治疗和预后方面极具价值。我们的综述可能有助于进一步了解circRNA介导的肿瘤细胞周期调控，并为基于circRNA的癌症治疗策略和生物学诊断研究提供见解。
