Hedges A, Wadsworth J, Turner P
Curr Med Res Opin. 1978;5(8):614-7. doi: 10.1185/03007997809110196.
Nefopam (90 mg), an analgesic, was compared with placebo in a double-blind trial in patients who had undergone total abdominal hysterectomy operations. Analgesic activity was assessed by patients rating their pain before and 1 hour after administration of each treatment, by sequential analysis of patient and observer preference for treatment, and by calculation of the time interval between doses of the two treatments. Nefopam was found by observer preference to be significantly better than placebo in relieving post-operative pain. In patients with severe initial pain, the time between doses after nefopam was significantly longer than after placebo.
在一项针对接受全腹子宫切除手术患者的双盲试验中，将镇痛药奈福泮（90毫克）与安慰剂进行了比较。通过让患者在每次治疗给药前和给药后1小时对疼痛进行评分、对患者和观察者对治疗的偏好进行序贯分析以及计算两种治疗剂量之间的时间间隔来评估镇痛活性。通过观察者的偏好发现，奈福泮在缓解术后疼痛方面明显优于安慰剂。在初始疼痛严重的患者中，服用奈福泮后的给药间隔时间明显长于服用安慰剂后的给药间隔时间。
