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三只接受苯丁酸氮芥和泼尼松龙治疗的猫的低有丝分裂指数鼻淋巴瘤

Nasal Lymphoma with Low Mitotic Index in Three Cats Treated with Chlorambucil and Prednisolone.

作者信息

Ng Karen W L, Beatty Julia A, Tse May P Y, Giuliano Antonio

机构信息

CityU Veterinary Medical Centre, City University of Hong Kong, Hong Kong.

Department of Veterinary Clinical Sciences, Jockey Club College of Veterinary Medicine, City University of Hong Kong, Hong Kong.

出版信息

Vet Sci. 2022 Sep 1;9(9):472. doi: 10.3390/vetsci9090472.

DOI:10.3390/vetsci9090472
PMID:36136688
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9503513/
Abstract

Lymphoma is the most common tumor of the nasal cavity in cats. Commonly used treatment modalities are radiotherapy and chemotherapy, or both. Typical chemotherapy protocols used in cats with nasal lymphoma are COP (cyclophosphamide, vincristine prednisolone) and CHOP (cyclophosphamide, doxorubicin, vincristine and prednisolone). Thus far, the use of single-agent chlorambucil in nasal lymphoma has been evaluated in a single case report. We report a case series of three cats with B cell nasal lymphoma, two cats with intermediate cell, and one large cell, all with a low mitotic index (MI) of less than 5 mitotic figures per ×400 field, treated with chlorambucil and prednisolone. Two of the cases achieved a long disease-free interval, while the one with the highest MI did not. Protocols using chlorambucil and prednisolone may have potential as a first-line therapy for feline nasal lymphoma cases with a very low mitotic index.

摘要

淋巴瘤是猫鼻腔最常见的肿瘤。常用的治疗方式是放疗和化疗，或两者结合。用于猫鼻腔淋巴瘤的典型化疗方案是COP（环磷酰胺、长春新碱、泼尼松龙）和CHOP（环磷酰胺、阿霉素、长春新碱和泼尼松龙）。到目前为止，在一篇单病例报告中评估了鼻腔淋巴瘤中单用苯丁酸氮芥的疗效。我们报告了一组病例，三只患有B细胞鼻腔淋巴瘤的猫、两只患有中间细胞型淋巴瘤的猫和一只患有大细胞型淋巴瘤的猫，所有猫的有丝分裂指数（MI）均较低，每400倍视野中少于5个有丝分裂象，均接受了苯丁酸氮芥和泼尼松龙治疗。其中两例实现了较长的无病间期，而有丝分裂指数最高的那例则没有。使用苯丁酸氮芥和泼尼松龙的方案可能有潜力作为有丝分裂指数极低的猫鼻腔淋巴瘤病例的一线治疗方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3432/9503513/b21301057d27/vetsci-09-00472-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3432/9503513/f79e0783b735/vetsci-09-00472-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3432/9503513/9f0e3a92d89d/vetsci-09-00472-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3432/9503513/0fd5794b9519/vetsci-09-00472-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3432/9503513/c4f5cf05b251/vetsci-09-00472-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3432/9503513/d7f2485dcd63/vetsci-09-00472-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3432/9503513/098b2d140059/vetsci-09-00472-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3432/9503513/47007f4bc980/vetsci-09-00472-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3432/9503513/838d39a3b5ee/vetsci-09-00472-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3432/9503513/b21301057d27/vetsci-09-00472-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3432/9503513/f79e0783b735/vetsci-09-00472-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3432/9503513/9f0e3a92d89d/vetsci-09-00472-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3432/9503513/0fd5794b9519/vetsci-09-00472-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3432/9503513/c4f5cf05b251/vetsci-09-00472-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3432/9503513/d7f2485dcd63/vetsci-09-00472-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3432/9503513/098b2d140059/vetsci-09-00472-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3432/9503513/47007f4bc980/vetsci-09-00472-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3432/9503513/838d39a3b5ee/vetsci-09-00472-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3432/9503513/b21301057d27/vetsci-09-00472-g009.jpg

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引用本文的文献

[1]
Partial Remission Without Recurrence in a 9-Year-Old Golden Retriever with Nasal Carcinoma Treated with Prednisolone/Chlorambucil Metronomic Combination Therapy: A Case Report and Literature Review of Molecular Mechanisms.

Curr Issues Mol Biol. 2025-8-15

[2]
The Expression Levels of CD20 as a Prognostic Value in Feline B-Cell Nasal Lymphoma: A Pilot Study.

Animals (Basel). 2024-3-29

[3]
Hybrid Models Based on Fusion Features of a CNN and Handcrafted Features for Accurate Histopathological Image Analysis for Diagnosing Malignant Lymphomas.

Diagnostics (Basel). 2023-7-4

[4]
Spotlight on Feline Oncology.

Vet Sci. 2023-3-24

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Open Vet J. 2021

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