Santagostino S F, Mortellaro C M, Boracchi P, Avallone G, Caniatti M, Forlani A, Roccabianca P
DIVET, Facoltà di Medicina Veterinaria, Università degli Studi di Milano, Milano, Italy
DIVET, Facoltà di Medicina Veterinaria, Università degli Studi di Milano, Milano, Italy.
Vet Pathol. 2015 Mar;52(2):250-9. doi: 10.1177/0300985814537529. Epub 2014 Jun 5.
Lymphoma is the most common feline upper respiratory tract (URT) tumor. Primary nasal and nasopharyngeal lymphomas have been evaluated as distinct pathological entities; however, data on their differing clinical behavior are missing. A total of 164 endoscopic- guided URT pinch biopsies were formalin fixed and routinely processed. Imprint cytological specimens were stained with May Grünwald-Giemsa. Immunohistochemistry for anti-CD20, CD3, FeLVp27, and FeLVgp70 was performed. Prognostic significance of clinicopathological variables was investigated by univariate and multivariate analysis. Lymphoma was diagnosed in 39 cats (24%). Most cats with lymphoma were domestic shorthair (32 [82%]), were male (F/M = 0.56), and had a mean age of 10.3 years (range, 1-16 years). Lymphomas were primary nasal in 26 cats (67%), nasopharyngeal in 6 (15%), and in both locations (combined lymphomas) in 7 cats (18%). Neoplastic growth pattern was diffuse in 35 cases (90%) and nodular in 4 (10%). Epitheliotropism was observed in 10 cases (26%). Tumor cells were large in 15 cases, were small and medium in 11 cases each, and 2 had mixed cell size. Submucosal lymphoplasmacytic inflammation was observed in 23 cases (59%). Cytology was diagnostic for lymphoma in 12 of 25 cases (48%). A B-cell origin prevailed (34 [87%]). Feline leukemia virus (FeLV) p27 or gp70 antigen was detected in 21 lymphomas (54%). URT lymphomas were aggressive, with survival varying from 0 to 301 days (mean, 53 days). Epitheliotropism in 8 B-cell lymphomas (80%) and in 2 T-cell lymphomas (20%) correlated with prolonged survival. Age younger or older than 10 years had a negative prognostic value. Lymphoplasmacytic inflammation and FeLV infection may represent favoring factors for URT lymphoma development.
淋巴瘤是猫最常见的上呼吸道（URT）肿瘤。原发性鼻腔和鼻咽淋巴瘤已被评估为不同的病理实体；然而，关于它们不同临床行为的数据却缺失。总共164份经内镜引导的URT夹取活检标本用福尔马林固定并常规处理。印片细胞学标本用美蓝-吉姆萨染色。进行了抗CD20、CD3、猫白血病病毒（FeLV）p27和FeLV gp70的免疫组织化学检测。通过单因素和多因素分析研究临床病理变量的预后意义。39只猫（24%）被诊断为淋巴瘤。大多数患淋巴瘤的猫是家养短毛猫（32只[82%]），为雄性（雌性/雄性=0.56），平均年龄为10.3岁（范围1 - 16岁）。淋巴瘤原发于鼻腔的有26只猫（67%），原发于鼻咽的有6只（15%），同时累及两个部位（联合淋巴瘤）的有7只猫（18%）。肿瘤生长模式为弥漫性的有35例（90%），结节性的有4例（10%）。10例（26%）观察到上皮趋向性。肿瘤细胞大的有15例，小和中等大小的各有11例，2例细胞大小混合。23例（59%）观察到黏膜下淋巴浆细胞炎症。25例中有12例（48%）细胞学诊断为淋巴瘤。以B细胞起源为主（34例[87%]）。21例淋巴瘤（54%）检测到FeLV p27或gp70抗原。URT淋巴瘤具有侵袭性，生存期从0至301天不等（平均53天）。8例B细胞淋巴瘤（80%）和2例T细胞淋巴瘤（20%）中的上皮趋向性与生存期延长相关。年龄小于或大于10岁具有负面预后价值。淋巴浆细胞炎症和FeLV感染可能是URT淋巴瘤发生的有利因素。
