MicroRNA-206 通过阻断 EVI-1 介导的 CALR 表达抑制乳腺癌干细胞的生长和转移。
MicroRNA-206 suppresses growth and metastasis of breast cancer stem cells via blocking EVI-1-mediated CALR expression.
机构信息
Department of Clinical Pharmaceutics, The First Affiliated Hospital of JINZHOU Medical University, Jinzhou, China.
Department of Critical Care Medicine, The First Affiliated Hospital of JINZHOU Medical University, Jinzhou, China.
出版信息
PLoS One. 2022 Sep 22;17(9):e0274919. doi: 10.1371/journal.pone.0274919. eCollection 2022.
Aim to investigate the effect of miR-206 on the growth and metastasis of breast cancer stem cells and clarify the precise mechanism of miR-206 on EVI-1-mediated CALR expression in driving malignant phenotype. Our results showed that miR-206 mimics suppressed CALR expression, inhibited the proliferation and metastasis ability of breast cancer stem cells and finally induced cellular apoptosis. Over-expression of CALR could effectively attenuate the cytotoxic effect of miR-206. Further studies demonstrated that EVI-1 could be served as a key regulator of miR206-mediated CALR expression. Elevation of EVI-1 can reverse the function of miR-206 on induction of CALR.
目的在于研究 miR-206 对乳腺癌干细胞生长和转移的影响，并阐明 miR-206 对 EVI-1 介导的 CALR 表达在驱动恶性表型中的确切机制。我们的结果表明，miR-206 模拟物抑制 CALR 表达，抑制乳腺癌干细胞的增殖和转移能力，最终诱导细胞凋亡。CALR 的过表达可以有效减弱 miR-206 的细胞毒性作用。进一步的研究表明，EVI-1 可以作为 miR206 介导的 CALR 表达的关键调节剂。EVI-1 的升高可以逆转 miR-206 对 CALR 诱导的功能。
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