The Department of Anesthesiology, Handan Central Hospital, Handan, China.
The Department of Anesthesiology, Hebei General Hospital, Shijiazhuang, China.
Aging (Albany NY). 2021 Jun 14;13(12):16341-16352. doi: 10.18632/aging.203160.
Breast cancer is a prevalent malignancy with high mortality and poor prognosis. Ropivacaine is a widely used local anesthetic and presents potential anti-tumor activity. Nevertheless, the function of ropivacaine in breast cancer development remains elusive. Here, we tried to investigate the impact of ropivacaine on breast cancer progression and the underlying mechanism. Significantly, we revealed that ropivacaine was able to reduce the proliferation and induce the apoptosis of breast cancer cells. Ropivacaine could attenuate the invasion and migration in the cells. Mechanically, ropivacaine could enhance the miR-27b-3p expression and miR-27b-3p inhibited breast cancer progression in breast cancer cells. MiR-27b-3p targeted YAP in the breast cancer cells. Ropivacaine decreased the breast cancer progression by modulating miR-27b-3p/YAP axis . Ropivacaine could inhibit tumor growth . In conclusion, we discovered that the local anesthetic ropivacaine inhibits the progression of breast cancer the miR-27b-3p/YAP axis. Our finding presents novel insights into the mechanism of ropivacaine inhibiting the development of breast cancer. Ropivacaine may potentially serve as an anti-tumor candidate in the therapeutic strategy of breast cancer.
乳腺癌是一种常见的恶性肿瘤，死亡率高，预后差。罗哌卡因是一种广泛应用的局部麻醉剂，具有潜在的抗肿瘤活性。然而，罗哌卡因在乳腺癌发展中的作用仍不清楚。在这里，我们试图研究罗哌卡因对乳腺癌进展的影响及其潜在机制。重要的是，我们发现罗哌卡因能够减少乳腺癌细胞的增殖并诱导其凋亡。罗哌卡因还可以减弱细胞的侵袭和迁移。在机制上，罗哌卡因能够增强 miR-27b-3p 的表达，而 miR-27b-3p 能够抑制乳腺癌细胞中的乳腺癌进展。miR-27b-3p 在乳腺癌细胞中靶向 YAP。罗哌卡因通过调节 miR-27b-3p/YAP 轴抑制乳腺癌进展。罗哌卡因可以抑制肿瘤生长。总之，我们发现局部麻醉剂罗哌卡因通过 miR-27b-3p/YAP 轴抑制乳腺癌的进展。我们的发现为罗哌卡因抑制乳腺癌发展的机制提供了新的见解。罗哌卡因可能在乳腺癌的治疗策略中作为一种抗肿瘤候选药物。
