Athinoula A.Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, USA; Department of Radiology, Harvard Medical School, Boston, MA, USA; Harvard-Massachusetts Institute of Technology Health Sciences & Technology, Cambridge, MA, USA.
Athinoula A.Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, USA; Medical Image Analysis and Biometry Laboratory, Universidad Rey Juan Carlos, Madrid, Spain.
Neuroimage Clin. 2022;36:103199. doi: 10.1016/j.nicl.2022.103199. Epub 2022 Sep 16.
Amyotrophic lateral sclerosis (ALS) is a deadly neurodegenerative disorder affecting motor neurons in the spinal cord and brain. Studies have reported on atrophy within segments of the cervical cord, but we are not aware of previous investigations of the whole spinal cord. Herein we present our findings from a 3T MRI study involving 32 subjects (15 ALS participants and 17 healthy controls) characterizing cross-sectional area along the entire cord. We report atrophy of the cervical enlargement in ALS participants, but no evidence of atrophy of the thoracolumbar enlargement. These results suggest that MR-based analyses of the cervical cord may be sufficient for in vivo investigations of spinal cord atrophy in ALS, and that atrophy of the cervical enlargement (C4-C7) is a potential imaging marker for quantifying lower motor neuron degradation.
肌萎缩侧索硬化症（ALS）是一种致命的神经退行性疾病，影响脊髓和大脑中的运动神经元。研究报告了颈椎节段内的萎缩，但我们不知道以前对整个脊髓的调查。本文介绍了我们在一项涉及 32 名受试者（15 名 ALS 参与者和 17 名健康对照者）的 3T MRI 研究中的发现，该研究描述了整个脊髓的横截面积。我们报告 ALS 参与者的颈膨大部萎缩，但没有胸腰椎膨大部萎缩的证据。这些结果表明，基于 MRI 的颈椎分析可能足以用于 ALS 中脊髓萎缩的体内研究，并且颈膨大部（C4-C7）的萎缩是量化下运动神经元退化的潜在成像标志物。
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