Paty J, Bourgeois M
Encephale. 1978;4(3):251-65.
We report 16 cases in which there is a dangerous potentialization of psychotropic drugs with dipropylacetamide, and compare them with 19 cases possible to control, that dipropylacetamide used alone, or in another association, was well tolerated. We pointed out the importance of a depressive evolution, and of dangerous associations, mainly with tricyclic compounds, lorazepam and 5-hydroxytryptamine. Clinical signs are described; they consist in a fast evolutive syndrome, which is the same that "syndrome malin of psychotrops" with neurovegetative signs and central fever, or ingravescent wakefulness disorders and spasmodic cerebellar signs. The importance for the diagnosis and the prognosis of E.E.G. data is pointed out; plasma levels determination does not seem to give important data. Drugs interactions studies are very important in the clinical evaluation of psychotrops. Several drugs may interact with dipropylacetamide. This fact sustains some hypothesises about the action site of the drug.
我们报告了16例精神药物与二丙基乙酰胺产生危险协同作用的病例，并将它们与19例可控制的病例进行比较，后者单独使用二丙基乙酰胺或与其他药物联合使用时耐受性良好。我们指出了抑郁性病程以及危险联合用药的重要性，主要是与三环类化合物、劳拉西泮和5-羟色胺的联合使用。描述了临床体征；它们表现为一种快速进展的综合征，与伴有神经植物性体征和中枢性发热的“精神药物恶性综合征”相同，或进行性觉醒障碍和痉挛性小脑体征。指出了脑电图数据对诊断和预后的重要性；血浆水平测定似乎并未提供重要数据。药物相互作用研究在精神药物的临床评估中非常重要。几种药物可能与二丙基乙酰胺发生相互作用。这一事实支持了关于该药物作用部位的一些假设。
