Salt A N, Melichar I, Thalmann R
Laryngoscope. 1987 Aug;97(8 Pt 1):984-91.
It is commonly accepted that the endocochlear potential (EP) of the cochlea is generated by an electrogenic transport of potassium into scala media by the marginal cells of stria vascularis. We have studied the potential and potassium concentration gradients as stria vascularis was penetrated with double-barreled potassium selective electrodes in the guinea pig cochlea. Our data demonstrate that a region exists in stria which is positively polarized (higher than the EP), but which has a low (perilymph-like) potassium composition. It is concluded that EP cannot be generated by the marginal cells alone but may involve passive potassium movement across the apical membranes of the basal cells. A model is presented which is consistent with many anatomical and physiological features of stria vascularis.
人们普遍认为，耳蜗的内淋巴电位（EP）是由血管纹边缘细胞将钾离子电转运到中阶产生的。我们通过在豚鼠耳蜗中用双管钾选择性电极穿透血管纹来研究电位和钾浓度梯度。我们的数据表明，血管纹中存在一个区域，该区域呈正极化（高于EP），但其钾成分较低（类似外淋巴）。得出的结论是，EP不能仅由边缘细胞产生，可能还涉及钾离子通过基底细胞顶端膜的被动移动。本文提出了一个与血管纹的许多解剖和生理特征相一致的模型。
