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(Bonpl.)L. G. Lohmann 叶的治疗潜力:植物学方面、植物化学和生物学、抗炎、抗氧化和愈合作用。

Therapeutic Potential of Leaves from (Bonpl.) L. G. Lohmann: Botanical Aspects, Phytochemical and Biological, Anti-Inflammatory, Antioxidant and Healing Action.

机构信息

Basic and Applied Graduate Program-PPGIBA, Biological Science Institute, Federal University of Amazonas, Manaus 69080-900, Brazil.

Embrapa Western Amazonia, Manaus 69010-970, Brazil.

出版信息

Biomolecules. 2022 Aug 31;12(9):1208. doi: 10.3390/biom12091208.

Abstract

Plants of the species (Bonpl.) L. G. Lohmann (Bignoniaceae), which are widely distributed in Brazil and named crajiru in the state of Amazonas, are known in folk medicine as a traditional medicine in the form of a tea for the treatment of intestinal colic, diarrhea, and anemia, among other diseases. The chemical analysis of extracts of the leaves has identified phenolic compounds, a class of secondary metabolites that provide defense for plants and benefits to the health of humans. Several studies have shown the therapeutic efficacy of extracts, with antitumor, antiviral, wound healing, anti-inflammatory, and antioxidant activities being among the therapeutic applications already proven. The healing action of leaf extract has been demonstrated in several experimental models, and shows the ability to favor the proliferation of fibroblasts, which is essential for tissue repair. The anti-inflammatory activity of F. chica has been clearly demonstrated by several authors, who suggest that it is related to the presence of 3-deoxyanthocyanidins, which is capable of inhibiting pro-inflammatory pathways such as the kappa B (NF-kB) nuclear transcription factor pathway. Another important effect attributed to this species is the antioxidant effect, attributed to phenolic compounds interrupting chain reactions caused by free radicals and donating hydrogen atoms or electrons. In conclusion, the species has great therapeutic potential, which is detailed in this paper with the objective of encouraging new research and promoting the sum of efforts for the inclusion of herbal medicines in health systems around the world.

摘要

(Bonpl.)L. G. Lohmann(紫葳科)植物,广泛分布于巴西,在亚马逊州被称为 crajiru,在民间医学中被用作茶的形式,用于治疗肠绞痛、腹泻和贫血等疾病。对叶片提取物的化学分析已经确定了酚类化合物,这是一类为植物提供防御和有益于人类健康的次生代谢物。多项研究表明提取物具有治疗功效,具有抗肿瘤、抗病毒、伤口愈合、抗炎和抗氧化活性等已被证实的治疗应用。叶片提取物的愈合作用已在几种实验模型中得到证明,并显示出有利于成纤维细胞增殖的能力,这对于组织修复至关重要。几位作者清楚地证明了 F. chica 的抗炎活性,他们认为这与 3-去氧花色苷的存在有关,3-去氧花色苷能够抑制核转录因子κ B(NF-κB)等促炎途径。该物种的另一个重要作用是抗氧化作用,酚类化合物通过中断自由基引起的链式反应并提供氢原子或电子来实现。总之,该物种具有巨大的治疗潜力,本文详细介绍了这一点,旨在鼓励新的研究,并促进为将草药纳入世界各地的卫生系统而做出的努力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ec3/9496332/a14c3d0daafe/biomolecules-12-01208-g001.jpg

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