Área de Farmacologia, Departamento de Ciências Básicas em Saúde, Faculdade de Medicina, Universidade Federal de Mato Grosso, Cuiabá, Brazil.
Departamento de Química, Instituto de Ciências Exatas e da Terra, Universidade Federal de Mato Grosso, Cuiabá, Brazil.
Nat Prod Res. 2020 Mar;34(5):726-730. doi: 10.1080/14786419.2018.1495636. Epub 2018 Nov 16.
Bignoniaceae, is a tropical tree-creeper used as a traditional remedy for a number of diseases, highlighting inflammation. Our objective was to corroborate the popular anti-inflammatory use of the hydroethanolic extract from the leaves (HEFc) and of its isolated 4',6,7-trihydroxy-5-methoxyflavone (5--methylscutellarein) [], described here for the first time. Quantitative analysis indicated 8.77 ± 0.23 mg/g of this compound in the extract. Neither HEFc nor [] was cytotoxic . In LPS-induced peritonitis in mice, oral pre-treatment with HEFc or [] led to decreased leukocyte migration to the peritoneal cavity and a reduction in the concentrations of pro-inflammatory cytokines (TNFα and IL-1β). Also, the anti-inflammatory cytokine IL-10 was enhanced following treatment with []. Overall, these results validate the traditional use of as anti-inflammatory, and indicate that the compound 5--methylscutellarein may participate in this effect.
紫葳科植物，是一种热带树栖攀缘植物，被用作许多疾病的传统疗法，特别是炎症。我们的目的是证实从叶片中提取的水-乙醇提取物（HEFc）及其分离得到的 4'，6，7-三羟基-5-甲氧基黄酮（5--甲基黄芩素）[]的民间抗炎用途，[]在这里首次被描述。定量分析表明提取物中含有 8.77±0.23mg/g 的这种化合物。HEFc 或 []均无细胞毒性。在 LPS 诱导的小鼠腹膜炎中，口服预先用 HEFc 或 []处理可减少白细胞向腹腔迁移，并降低促炎细胞因子（TNFα 和 IL-1β）的浓度。此外，用 []处理后抗炎细胞因子 IL-10 增强。总的来说，这些结果验证了 作为抗炎药的传统用途，并表明化合物 5--甲基黄芩素可能参与了这种作用。
