Blukacz Łukasz, Nowak Artur, Wójtowicz Mariusz, Krawczyk Angelika, Franik Grzegorz, Madej Paweł, Pluta Dagmara, Kowalczyk Karolina, Żorniak Michał
Department of Gynecological Endocrinology, School of Medicine in Katowice, Medical University of Silesia, 40-752 Katowice, Poland.
Gynecological and Obstetrician Polyclinic, 15-435 Białystok, Poland.
Biomedicines. 2022 Sep 5;10(9):2193. doi: 10.3390/biomedicines10092193.
The coexistence of polycystic ovary syndrome (PCOS) and liver steatosis has been studied for years. The gold standards for the diagnosis of liver steatosis are liver biopsy and magnetic resonance imaging (MRI), which are invasive and expensive methods. The main aim of this study is to check the usefulness of lipid accumulation product (LAP) and free androgen index (FAI) in the diagnosis of liver steatosis. The Ideal IQ MRI was performed in 49 women with PCOS phenotype A to assess the degree of liver steatosis, which was expressed with the proton density fat fraction (PDFF). Anthropometric examination and laboratory tests were performed, and the LAP and FAI were calculated. The correlation between MRI results and LAP, FAI, and one of the FAI components, sex hormone binding globulin (SHBG), was checked using statistical tests. There is a statistically significant correlation between PDFF and LAP and also between PDFF and FAI. LAP = 70.25 and FAI = 5.05 were established as cut-offs to diagnose liver steatosis. The SHBG is not a statistically significant parameter to predict liver steatosis. The study showed that especially LAP, but also FAI, can be used to predict liver steatosis with high specificity and sensitivity.
多囊卵巢综合征（PCOS）与肝脂肪变性的共存已经研究多年。肝脂肪变性诊断的金标准是肝活检和磁共振成像（MRI），这两种方法具有侵入性且费用高昂。本研究的主要目的是检验脂质蓄积产物（LAP）和游离雄激素指数（FAI）在肝脂肪变性诊断中的实用性。对49例A表型PCOS女性进行了Ideal IQ MRI检查，以评估肝脂肪变性程度，用质子密度脂肪分数（PDFF）表示。进行了人体测量检查和实验室检测，并计算了LAP和FAI。使用统计检验检查MRI结果与LAP、FAI以及FAI组分之一性激素结合球蛋白（SHBG）之间的相关性。PDFF与LAP之间以及PDFF与FAI之间存在统计学显著相关性。将LAP = 70.25和FAI = 5.05确定为诊断肝脂肪变性的临界值。SHBG不是预测肝脂肪变性的统计学显著参数。研究表明，尤其是LAP，还有FAI，可用于以高特异性和敏感性预测肝脂肪变性。
