Department of Pediatrics, Steele Children's Research Center, The University of Arizona, Tucson, AZ 85721, USA.
Int J Mol Sci. 2022 Sep 17;23(18):10857. doi: 10.3390/ijms231810857.
The Na/H exchanger transporters (NHE) play an important role in various biologic processes including Na absorption, intracellular pH homeostasis, cell volume regulation, proliferation, and apoptosis. The wide expression pattern and cellular localization of NHEs make these proteins pivotal players in virtually all human tissues and organs. In addition, recent studies suggest that NHEs may be one of the primeval transport protein forms in the history of life. Among the different isoforms, the most well-characterized NHEs are the Na/H exchanger isoform 1 (NHE1) and Na/H exchanger isoform 3 (NHE3). However, Na/H exchanger isoform 8 (NHE8) has been receiving attention based on its recent discoveries in the gastrointestinal tract. In this review, we will discuss what is known about the physiological function and potential role of NHE8 in the main organ systems, including useful overviews that could inspire new studies on this multifaceted protein.
钠/氢交换体转运蛋白（NHE）在多种生物学过程中发挥重要作用，包括钠吸收、细胞内 pH 稳态、细胞体积调节、增殖和凋亡。NHE 的广泛表达模式和细胞定位使这些蛋白成为几乎所有人类组织和器官中关键的参与者。此外，最近的研究表明，NHE 可能是生命史上最原始的转运蛋白形式之一。在不同的同工型中，研究最充分的 NHE 是钠/氢交换体同工型 1（NHE1）和钠/氢交换体同工型 3（NHE3）。然而，基于其在胃肠道中的最新发现，钠/氢交换体同工型 8（NHE8）受到了关注。在这篇综述中，我们将讨论关于 NHE8 在主要器官系统中的生理功能和潜在作用的已知信息，包括有用的概述，这可能激发对这种多方面蛋白的新研究。
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