Zhang Shasha, Qiang Ruiying, Dong Ying, Zhang Yuan, Chen Yin, Zhou Han, Gao Xia, Chai Renjie
Key Laboratory for Developmental Genes and Human Disease, Ministry of Education, Institute of Life Sciences, Southeast University Nanjing 210096, China.
Department of Otolaryngology Head and Neck Surgery, Affiliated Drum Tower Hospital of Nanjing University Medical School, Jiangsu Provincial Key Medical Discipline (Laboratory) Nanjing 210008, China.
Am J Stem Cells. 2020 Jun 15;9(3):25-35. eCollection 2020.
Cochlear hair cells (HCs) are the mechanoreceptors of the auditory system, and because these cells cannot be spontaneously regenerated in adult mammals, hearing loss due to HC damage is permanent. However, cochleae of neonatal mice harbor some progenitor cells that retain limited ability to give rise to new HCs . Here we review the regulatory factors, signaling pathways, and epigenetic factors that have been reported to play roles in HC regeneration in the neonatal mammalian cochlea.
耳蜗毛细胞（HCs）是听觉系统的机械感受器，由于这些细胞在成年哺乳动物中无法自发再生，因此因HC损伤导致的听力损失是永久性的。然而，新生小鼠的耳蜗含有一些祖细胞，这些祖细胞具有产生新HCs的有限能力。在这里，我们综述了据报道在新生哺乳动物耳蜗HC再生中起作用的调节因子、信号通路和表观遗传因子。
