哺乳动物耳蜗中内耳祖细胞的毛细胞再生。
Hair cell regeneration from inner ear progenitors in the mammalian cochlea.
作者信息
Zhang Shasha, Qiang Ruiying, Dong Ying, Zhang Yuan, Chen Yin, Zhou Han, Gao Xia, Chai Renjie
机构信息
Key Laboratory for Developmental Genes and Human Disease, Ministry of Education, Institute of Life Sciences, Southeast University Nanjing 210096, China.
Department of Otolaryngology Head and Neck Surgery, Affiliated Drum Tower Hospital of Nanjing University Medical School, Jiangsu Provincial Key Medical Discipline (Laboratory) Nanjing 210008, China.
出版信息
Am J Stem Cells. 2020 Jun 15;9(3):25-35. eCollection 2020.
Abstract
Cochlear hair cells (HCs) are the mechanoreceptors of the auditory system, and because these cells cannot be spontaneously regenerated in adult mammals, hearing loss due to HC damage is permanent. However, cochleae of neonatal mice harbor some progenitor cells that retain limited ability to give rise to new HCs . Here we review the regulatory factors, signaling pathways, and epigenetic factors that have been reported to play roles in HC regeneration in the neonatal mammalian cochlea.
摘要
耳蜗毛细胞（HCs）是听觉系统的机械感受器，由于这些细胞在成年哺乳动物中无法自发再生，因此因HC损伤导致的听力损失是永久性的。然而，新生小鼠的耳蜗含有一些祖细胞，这些祖细胞具有产生新HCs的有限能力。在这里，我们综述了据报道在新生哺乳动物耳蜗HC再生中起作用的调节因子、信号通路和表观遗传因子。
相似文献
1
Hair cell regeneration from inner ear progenitors in the mammalian cochlea.哺乳动物耳蜗中内耳祖细胞的毛细胞再生。
Am J Stem Cells. 2020 Jun 15;9(3):25-35. eCollection 2020.
2
Hedgehog Signaling Promotes the Proliferation and Subsequent Hair Cell Formation of Progenitor Cells in the Neonatal Mouse Cochlea.刺猬信号通路促进新生小鼠耳蜗中祖细胞的增殖及随后的毛细胞形成。
Front Mol Neurosci. 2017 Dec 21;10:426. doi: 10.3389/fnmol.2017.00426. eCollection 2017.
3
In Vivo Cochlear Hair Cell Generation and Survival by Coactivation of β-Catenin and Atoh1.通过β-连环蛋白和Atoh1的共激活在体内产生和存活耳蜗毛细胞
J Neurosci. 2015 Jul 29;35(30):10786-98. doi: 10.1523/JNEUROSCI.0967-15.2015.
4
Hair Cell Regeneration.毛细胞再生。
Adv Exp Med Biol. 2019;1130:1-16. doi: 10.1007/978-981-13-6123-4_1.
5
Cochlear hair cell regeneration after noise-induced hearing loss: Does regeneration follow development?噪声性听力损失后的耳蜗毛细胞再生：再生过程与发育过程相似吗？
Hear Res. 2017 Jun;349:182-196. doi: 10.1016/j.heares.2016.12.011. Epub 2016 Dec 26.
6
Auditory hair cell-specific deletion of p27Kip1 in postnatal mice promotes cell-autonomous generation of new hair cells and normal hearing.在出生后的小鼠中，听觉毛细胞特异性敲除 p27Kip1 可促进细胞自主产生新的毛细胞并维持正常听力。
J Neurosci. 2014 Nov 19;34(47):15751-63. doi: 10.1523/JNEUROSCI.3200-14.2014.
7
Selective ablation of inner hair cells and subsequent in-situ hair cell regeneration in the neonatal mouse cochlea.新生小鼠耳蜗内毛细胞的选择性消融及随后的原位毛细胞再生
Hear Res. 2021 Aug;407:108275. doi: 10.1016/j.heares.2021.108275. Epub 2021 May 23.
8
Wnt activation followed by Notch inhibition promotes mitotic hair cell regeneration in the postnatal mouse cochlea.Wnt激活后紧接着Notch抑制可促进出生后小鼠耳蜗中有丝分裂的毛细胞再生。
Oncotarget. 2016 Oct 11;7(41):66754-66768. doi: 10.18632/oncotarget.11479.
9
Diphtheria Toxin-Induced Cell Death Triggers Wnt-Dependent Hair Cell Regeneration in Neonatal Mice.白喉毒素诱导的细胞死亡触发新生小鼠中依赖Wnt的毛细胞再生。
J Neurosci. 2016 Sep 7;36(36):9479-89. doi: 10.1523/JNEUROSCI.2447-15.2016.
10
Spontaneous Hair Cell Regeneration Is Prevented by Increased Notch Signaling in Supporting Cells.支持细胞中Notch信号增加会阻止毛细胞的自发再生。
Front Cell Neurosci. 2018 May 4;12:120. doi: 10.3389/fncel.2018.00120. eCollection 2018.
引用本文的文献
1
Relationship between hearing thresholds and cognitive function in hearing aid non-users and long-term users post-midlife.中年后未使用助听器者和长期使用者的听力阈值与认知功能之间的关系。
NPJ Aging. 2025 Feb 24;11(1):14. doi: 10.1038/s41514-025-00203-6.
2
SIRT3 regulates PFKFB3-mediated glycolysis to attenuate cisplatin-induced ototoxicity both in vivo and in vitro.SIRT3调节PFKFB3介导的糖酵解，以减轻顺铂在体内和体外诱导的耳毒性。
Arch Toxicol. 2025 May;99(5):2143-2156. doi: 10.1007/s00204-025-03975-8. Epub 2025 Feb 13.
3
Conditional Overexpression of Net1 Enhances the Trans-Differentiation of Lgr5 Progenitors into Hair Cells in the Neonatal Mouse Cochlea.Net1的条件性过表达增强新生小鼠耳蜗中Lgr5祖细胞向毛细胞的转分化。
Cell Prolif. 2025 Apr;58(4):e13787. doi: 10.1111/cpr.13787. Epub 2024 Dec 15.
4
Reprogramming with , , and promotes hair cell regeneration in the adult organ of Corti.使用 、 和 进行重编程可促进成年柯蒂氏器中的毛细胞再生。
PNAS Nexus. 2024 Oct 4;3(10):pgae445. doi: 10.1093/pnasnexus/pgae445. eCollection 2024 Oct.
5
Hearing Loss and Oxidative Stress: A Comprehensive Review.听力损失与氧化应激：全面综述
Antioxidants (Basel). 2024 Jul 14;13(7):842. doi: 10.3390/antiox13070842.
6
Tissue Engineering and Regenerative Medicine in the Field of Otorhinolaryngology.耳鼻喉科学领域中的组织工程和再生医学。
Tissue Eng Regen Med. 2024 Oct;21(7):969-984. doi: 10.1007/s13770-024-00661-1. Epub 2024 Jul 17.
7
AAV-mediated Gene Cocktails Enhance Supporting Cell Reprogramming and Hair Cell Regeneration.AAV 介导的基因鸡尾酒增强支持细胞的重编程和毛细胞再生。
Adv Sci (Weinh). 2024 Aug;11(29):e2304551. doi: 10.1002/advs.202304551. Epub 2024 May 29.
8
The Suppression of Ubiquitin C-Terminal Hydrolase L1 Promotes the Transdifferentiation of Auditory Supporting Cells into Hair Cells by Regulating the mTOR Pathway.泛素 C 端水解酶 L1 的抑制通过调节 mTOR 通路促进听觉支持细胞向毛细胞的转分化。
Cells. 2024 Apr 24;13(9):737. doi: 10.3390/cells13090737.
9
TRIM71 reactivation enhances the mitotic and hair cell-forming potential of cochlear supporting cells.TRIM71 的重新激活增强了耳蜗支持细胞的有丝分裂和毛细胞形成潜力。
EMBO Rep. 2023 Sep 6;24(9):e56562. doi: 10.15252/embr.202256562. Epub 2023 Jul 26.
10
Rps14 upregulation promotes inner ear progenitor proliferation and hair cell regeneration in the neonatal mouse cochlea.Rps14 上调促进新生小鼠耳蜗内细胞前体增殖和毛细胞再生。
Cell Prolif. 2023 May;56(5):e13458. doi: 10.1111/cpr.13458. Epub 2023 Mar 28.
本文引用的文献
1
Knockdown of Foxg1 in supporting cells increases the trans-differentiation of supporting cells into hair cells in the neonatal mouse cochlea.敲低支持细胞中的 Foxg1 会增加新生小鼠耳蜗中支持细胞向毛细胞的转分化。
Cell Mol Life Sci. 2020 Apr;77(7):1401-1419. doi: 10.1007/s00018-019-03291-2. Epub 2019 Sep 4.
2
Frizzled-9+ Supporting Cells Are Progenitors for the Generation of Hair Cells in the Postnatal Mouse Cochlea.卷曲蛋白9阳性支持细胞是出生后小鼠耳蜗中毛细胞生成的祖细胞。
Front Mol Neurosci. 2019 Jul 31;12:184. doi: 10.3389/fnmol.2019.00184. eCollection 2019.
3
Mechanisms of Hair Cell Damage and Repair.毛细胞损伤与修复的机制。
Trends Neurosci. 2019 Jun;42(6):414-424. doi: 10.1016/j.tins.2019.03.006. Epub 2019 Apr 13.
4
Hippo Signaling Pathway Dysregulation in Human Huntington's Disease Brain and Neuronal Stem Cells.人类亨廷顿病脑中的 Hippo 信号通路失调和神经干细胞。
Sci Rep. 2018 Jul 27;8(1):11355. doi: 10.1038/s41598-018-29319-4.
5
Characterization of Lgr6+ Cells as an Enriched Population of Hair Cell Progenitors Compared to Lgr5+ Cells for Hair Cell Generation in the Neonatal Mouse Cochlea.与Lgr5 +细胞相比，Lgr6 +细胞作为毛细胞祖细胞富集群体在新生小鼠耳蜗毛细胞生成中的特性研究。
Front Mol Neurosci. 2018 May 14;11:147. doi: 10.3389/fnmol.2018.00147. eCollection 2018.
6
Bone morphogenetic protein 4 antagonizes hair cell regeneration in the avian auditory epithelium.骨形态发生蛋白4拮抗鸟类听觉上皮中的毛细胞再生。
Hear Res. 2018 Jul;364:1-11. doi: 10.1016/j.heares.2018.04.008. Epub 2018 May 2.
7
The Hippo pathway in organ development, homeostasis, and regeneration.Hippo 通路在器官发育、稳态和再生中的作用。
Curr Opin Cell Biol. 2017 Dec;49:99-107. doi: 10.1016/j.ceb.2017.12.012. Epub 2018 Jan 6.
8
Hedgehog Signaling Promotes the Proliferation and Subsequent Hair Cell Formation of Progenitor Cells in the Neonatal Mouse Cochlea.刺猬信号通路促进新生小鼠耳蜗中祖细胞的增殖及随后的毛细胞形成。
Front Mol Neurosci. 2017 Dec 21;10:426. doi: 10.3389/fnmol.2017.00426. eCollection 2017.
9
Sonic hedgehog antagonists reduce size and alter patterning of the frog inner ear.声波刺猬拮抗剂可减小青蛙内耳的大小并改变其模式。
Dev Neurobiol. 2017 Dec;77(12):1385-1400. doi: 10.1002/dneu.22544. Epub 2017 Oct 24.
10
Hippo pathway - brief overview of its relevance in cancer.Hippo信号通路——其在癌症中的相关性简要概述。
J Physiol Pharmacol. 2017 Jun;68(3):311-335.
Zotero 插件