文献检索文档翻译深度研究
Suppr Zotero 插件Zotero 插件
邀请有礼套餐&价格历史记录

新学期，新优惠

限时优惠:9月1日-9月22日

30天高级会员仅需29元

1天体验卡首发特惠仅需5.99元

了解详情
不再提醒
插件&应用
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
高级版
套餐订阅购买积分包
AI 工具
文献检索文档翻译深度研究
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2025

一项关于晚发性败血症和坏死性小肠结肠炎新生儿血清代谢组学的前瞻性病例对照研究。

A Prospective, Case-Control Study of Serum Metabolomics in Neonates with Late-Onset Sepsis and Necrotizing Enterocolitis.

作者信息

Thomaidou Agathi, Deda Olga, Begou Olga, Lioupi Artemis, Kontou Angeliki, Gika Helen, Agakidou Eleni, Theodoridis Georgios, Sarafidis Kosmas

机构信息

1st Department of Neonatology, School of Medicine, Aristotle University of Thessaloniki, Hippokrateion General Hospital, 54642 Thessaloniki, Greece.

Laboratory of Forensic Medicine and Toxicology, School of Medicine, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.

出版信息

J Clin Med. 2022 Sep 7;11(18):5270. doi: 10.3390/jcm11185270.

DOI:10.3390/jcm11185270
PMID:36142917
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9505627/
Abstract

Late-onset sepsis (LOS) and necrotizing enterocolitis (NEC) are major causes of neonatal morbidity and mortality. In this prospective, case-control study, we evaluated the metabolic profile of neonates with LOS and NEC. Blood samples were collected from 15 septic neonates and 17 neonates with NEC at the clinical suspicion of the specific diseases. Sixteen gestational and postnatal age-matched neonates without sepsis/NEC served as controls. Serum metabolic profiles were assessed using liquid chromatography-quadrupole time-of-flight mass spectrometry. Metabolomic analysis revealed significant differences in the metabolic profile of neonates with LOS or NEC compared to controls. More specifically, a number of molecules possibly identified as phosphatidylcholines or lysophosphatidylcholines were found to be significantly reduced both in neonates with LOS and those with NEC compared to controls. Additionally, L-carnitine could efficiently discriminate NEC cases from controls. The results of the current study suggest that certain phospholipids and their derivatives could possibly be used as biomarkers for the early detection of LOS and NEC.

摘要

迟发性败血症（LOS）和坏死性小肠结肠炎（NEC）是新生儿发病和死亡的主要原因。在这项前瞻性病例对照研究中，我们评估了患有LOS和NEC的新生儿的代谢谱。在临床怀疑患有特定疾病时，从15名败血症新生儿和17名患有NEC的新生儿中采集血样。16名胎龄和出生后年龄匹配且无败血症/NEC的新生儿作为对照。使用液相色谱-四极杆飞行时间质谱法评估血清代谢谱。代谢组学分析显示，与对照组相比，患有LOS或NEC的新生儿的代谢谱存在显著差异。更具体地说，发现一些可能被鉴定为磷脂酰胆碱或溶血磷脂酰胆碱的分子在患有LOS的新生儿和患有NEC的新生儿中均比对照组显著减少。此外，左旋肉碱可以有效地区分NEC病例与对照组。本研究结果表明，某些磷脂及其衍生物可能用作早期检测LOS和NEC的生物标志物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0535/9505627/4a34f373caaa/jcm-11-05270-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0535/9505627/fd1a3e0c78af/jcm-11-05270-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0535/9505627/8fae31415d18/jcm-11-05270-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0535/9505627/3cf0162ae9d6/jcm-11-05270-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0535/9505627/0c85f078a7b3/jcm-11-05270-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0535/9505627/4a34f373caaa/jcm-11-05270-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0535/9505627/fd1a3e0c78af/jcm-11-05270-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0535/9505627/8fae31415d18/jcm-11-05270-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0535/9505627/3cf0162ae9d6/jcm-11-05270-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0535/9505627/0c85f078a7b3/jcm-11-05270-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0535/9505627/4a34f373caaa/jcm-11-05270-g005.jpg

相似文献

[1]
A Prospective, Case-Control Study of Serum Metabolomics in Neonates with Late-Onset Sepsis and Necrotizing Enterocolitis.

J Clin Med. 2022-9-7

[2]
Targeted LC-MS/MS for the evaluation of proteomics biomarkers in the blood of neonates with necrotizing enterocolitis and late-onset sepsis.

Anal Bioanal Chem. 2018-8-23

[3]
A pilot case-control study of urine metabolomics in preterm neonates with necrotizing enterocolitis.

J Chromatogr B Analyt Technol Biomed Life Sci. 2019-4-8

[4]
Risk factors of necrotizing enterocolitis in neonates with sepsis: A retrospective case-control study.

Int J Immunopathol Pharmacol. 2020

[5]
Vital signs analysis algorithm detects inflammatory response in premature infants with late onset sepsis and necrotizing enterocolitis.

Early Hum Dev. 2018-2

[6]
Urine metabolomics in neonates with late-onset sepsis in a case-control study.

Sci Rep. 2017-4-4

[7]
Metabolomic and proteomic analysis of serum from preterm infants with necrotising entercolitis and late-onset sepsis.

Pediatr Res. 2016-3

[8]
Interleukin-6 serum levels predict surgical intervention in infants with necrotizing enterocolitis.

J Pediatr Surg. 2019-3

[9]
Elevated levels of circulating cell-free DNA and neutrophil proteins are associated with neonatal sepsis and necrotizing enterocolitis in immature mice, pigs and infants.

Innate Immun. 2017-8

[10]
Fecal amine metabolite analysis before onset of severe necrotizing enterocolitis in preterm infants: a prospective case-control study.

Sci Rep. 2022-7-19

引用本文的文献

[1]
Integrated analysis of serum metabolomics and fecal microbiome in infants with necrotizing enterocolitis.

Front Microbiol. 2025-6-5

[2]
Survival of the Littlest: Navigating Sepsis Diagnosis beyond Inflammation in Preterm Neonates.

J Proteome Res. 2025-6-6

[3]
Identification of serum metabolite biomarkers in premature infants with bronchopulmonary dysplasia: protocol for a multicentre prospective observational cohort study.

BMJ Open. 2025-1-15

[4]
Metabolomic analysis to predict the onset and severity of necrotizing enterocolitis.

BMC Gastroenterol. 2024-10-26

[5]
Struggling to Understand the NEC Spectrum-Could the Integration of Metabolomics, Clinical-Laboratory Data, and Other Emerging Technologies Help Diagnosis?

Metabolites. 2024-9-26

[6]
Metabolic and Microbial Dysregulation in Preterm Infants with Neonatal Respiratory Distress Syndrome: An Early Developmental Perspective.

J Proteome Res. 2024-8-2

[7]
Advances in Mass Spectrometry-Based Blood Metabolomics Profiling for Non-Cancer Diseases: A Comprehensive Review.

Metabolites. 2024-1-14

[8]
Metabolomics in NEC: An Updated Review.

Metabolites. 2023-12-24

本文引用的文献

[1]
Using MetaboAnalyst 5.0 for LC-HRMS spectra processing, multi-omics integration and covariate adjustment of global metabolomics data.

Nat Protoc. 2022-8

[2]
Biomarkers of Neonatal Sepsis: From Being Mere Numbers to Becoming Guiding Diagnostics.

Cureus. 2022-3-16

[3]
Fat of the Gut: Epithelial Phospholipids in Inflammatory Bowel Diseases.

Int J Mol Sci. 2021-10-28

[4]
Urine NMR Metabolomics Profile of Preterm Infants With Necrotizing Enterocolitis Over the First Two Months of Life: A Pilot Longitudinal Case-Control Study.

Front Mol Biosci. 2021-6-15

[5]
Untargeted and Targeted Metabolomic Profiling of Preterm Newborns with EarlyOnset Sepsis: A Case-Control Study.

Metabolites. 2021-2-18

[6]
Emerging Biomarkers for Prediction and Early Diagnosis of Necrotizing Enterocolitis in the Era of Metabolomics and Proteomics.

Front Pediatr. 2020-12-8

[7]
Diagnosis and mortality prediction of sepsis via lysophosphatidylcholine 16:0 measured by MALDI-TOF MS.

Sci Rep. 2020-8-14

[8]
Progressive Metabolic Dysfunction and Nutritional Variability Precedes Necrotizing Enterocolitis.

Nutrients. 2020-4-30

[9]
Meropenem vs standard of care for treatment of neonatal late onset sepsis (NeoMero1): A randomised controlled trial.

PLoS One. 2020-3-4

[10]
Contemporary Outcomes for Infants with Necrotizing Enterocolitis-A Systematic Review.

J Pediatr. 2020-1-22

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

推荐工具

医学文档翻译智能文献检索