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DNA定向促多巴胺调节与半脱位修复、H波及其他基于神经生物学的方法相结合,以解决一名被诊断为奖赏缺乏综合征(RDS)的女性慢性疼痛的复杂性:面对阿片类药物危机时“多巴胺稳态”诱导的出现。

DNA Directed Pro-Dopamine Regulation Coupling Subluxation Repair, H-Wave and Other Neurobiologically Based Modalities to Address Complexities of Chronic Pain in a Female Diagnosed with Reward Deficiency Syndrome (RDS): Emergence of Induction of "Dopamine Homeostasis" in the Face of the Opioid Crisis.

作者信息

Bajaj Anish, Blum Kenneth, Bowirrat Abdalla, Gupta Ashim, Baron David, Fugel David, Nicholson Ayo, Fitch Taylor, Downs B William, Bagchi Debasis, Dennen Catherine A, Badgaiyan Rajendra D

机构信息

Bajaj Chiropractic Clinic, New York, NY 10010, USA.

Division of Addiction Research & Education, Center for Psychiatry, Medicine, and Primary Care, (Office of the Provost), Western University Health Sciences, Pomona, CA 91766, USA.

出版信息

J Pers Med. 2022 Aug 30;12(9):1416. doi: 10.3390/jpm12091416.

DOI:10.3390/jpm12091416
PMID:36143203
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9503998/
Abstract

Addiction is a complex multifactorial condition. Established genetic factors can provide clear guidance in assessing the risk of addiction to substances and behaviors. Chronic stress can accumulate, forming difficult to recognize addiction patterns from both genetic and epigenetic (environmental) factors. Furthermore, psychological/physical/chemical stressors are typically categorized linearly, delaying identification and treatment. The patient in this case report is a Caucasian female, aged 36, who presented with chronic pain and partial disability following a surgically repaired trimalleolar fracture. The patient had a history of unresolved attention deficit disorder and an MRI scan of her brain revealed atrophy and functional asymmetry. In 2018, the patient entered the Bajaj Chiropractic Clinic, where initial treatment focused on re-establishing integrity of the spine and lower extremity biomechanics and graduated into cognitive behavior stabilization assisted by DNA pro-dopamine regulation guided by Genetic Addiction Risk Severity testing. During treatment (2018-2021), progress achieved included: improved cognitive clarity, focus, sleep, anxiety, and emotional stability in addition to pain reduction (75%); elimination of powerful analgesics; and reduced intake of previously unaddressed alcoholism. To help reduce hedonic addictive behaviors and pain, coupling of H-Wave with corrective chiropractic care seems prudent. We emphasize the importance of genetic assessment along with attempts at inducing required dopaminergic homeostasis via precision KB220PAM. It is hypothesized that from preventive care models, a new standard is emerging including self-awareness and accountability for reward deficiency as a function of hypodopaminergia. This case study documents the progression of a patient dealing with the complexities of an injury, pain management, cognitive impairment, anxiety, depression, and the application of universal health principles towards correction versus palliative care.

摘要

成瘾是一种复杂的多因素病症。已确定的遗传因素可为评估物质和行为成瘾风险提供明确指导。慢性应激会不断累积,从而难以从遗传和表观遗传(环境)因素中识别成瘾模式。此外,心理/身体/化学应激源通常按线性分类,这会延误识别和治疗。本病例报告中的患者是一名36岁的白种女性,因三踝骨折手术修复后出现慢性疼痛和部分残疾。该患者有未解决的注意力缺陷障碍病史,脑部MRI扫描显示萎缩和功能不对称。2018年,患者进入巴贾杰脊椎按摩诊所,初始治疗重点是恢复脊柱和下肢生物力学的完整性,并逐步发展为在遗传成瘾风险严重程度测试指导下的DNA前多巴胺调节辅助下的认知行为稳定治疗。在治疗期间(2018年至2021年),取得的进展包括:除疼痛减轻(75%)外,可以改善认知清晰度、注意力、睡眠、焦虑和情绪稳定性;停用强效镇痛药;减少之前未解决的酗酒问题。为了帮助减少享乐性成瘾行为和疼痛,将H波与矫正脊椎按摩治疗相结合似乎是明智的。我们强调遗传评估的重要性,以及通过精准KB220PAM诱导所需多巴胺能内稳态的尝试。据推测,从预防保健模式来看,一个新的标准正在出现,包括自我意识和对作为多巴胺能减退功能的奖励缺乏的问责。本案例研究记录了一名患者应对损伤、疼痛管理、认知障碍、焦虑、抑郁等复杂性问题的过程,以及普遍健康原则在矫正与姑息治疗中的应用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b86/9503998/7059d2347e11/jpm-12-01416-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b86/9503998/936f86aea3a9/jpm-12-01416-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b86/9503998/4a61c59d236b/jpm-12-01416-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b86/9503998/7059d2347e11/jpm-12-01416-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b86/9503998/936f86aea3a9/jpm-12-01416-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b86/9503998/4a61c59d236b/jpm-12-01416-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b86/9503998/7059d2347e11/jpm-12-01416-g003.jpg

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