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多种因素对发育性髋关节发育不良发生率的影响:风险评估工具。

Impact of Multiple Factors on the Incidence of Developmental Dysplasia of the Hip: Risk Assessment Tool.

机构信息

Department of Orthopaedics and Traumatology, Medical University of Warsaw, 02-005 Warsaw, Poland.

Department of Biostatistics and Translational Medicine, Medical University of Lodz, 92-215 Lodz, Poland.

出版信息

Medicina (Kaunas). 2022 Aug 25;58(9):1158. doi: 10.3390/medicina58091158.

Abstract

Background and Objectives: Developmental dysplasia of the hip (DDH) is one of the most common musculoskeletal conditions in children. If not treated, it leads to disability, gait abnormalities, limb shortening, and chronic pain. Our study aims to determine the impact of multiple risk factors on the incidence of DDH and to develop an interactive risk assessment tool. Materials and Methods: We conducted a retrospective cohort study in the Outpatient Clinic for Children of the Medical University of Warsaw Hospital. The Graf classification system was used for universal ultrasonographic screening. In total, 3102 infants met the eligibility criteria. Results: The incidence of DDH in the study group was 4.45%. The incidence of DDH in the Warsaw population, Poland, during the study period was 3.73 to 5.17 (95% CI). According to the multivariate analysis, the risk factors for DDH were birth weight (OR = 2.17 (1.41−3.32)), week of delivery (OR = 1.18 (1.00−1.37)), female sex (OR = 8.16 (4.86−13.71)), breech presentation (OR = 5.92 (3.37−10.40)), physical signs of DDH (25.28 (8.77−72.83)) and positive family history in siblings (5.74 (2.68−12.31)). Our results support the recent hypothesis that preterm infants (<37 weeks) have a lower rate of DDH. Conclusions: A multivariate logistic regression predictive model was used to build the risk calculator. The DDH risk calculator will be evaluated in a prospective validation study.

摘要

背景与目的

发育性髋关节发育不良(DDH)是儿童中最常见的骨骼肌肉疾病之一。如果不治疗,会导致残疾、步态异常、肢体缩短和慢性疼痛。本研究旨在确定多种危险因素对 DDH 发病率的影响,并开发一个交互式风险评估工具。

材料与方法

我们在华沙医科大学医院儿科门诊进行了回顾性队列研究。使用 Graf 分类系统进行了普遍的超声筛查。共有 3102 名婴儿符合入选标准。

结果

研究组 DDH 的发病率为 4.45%。研究期间,波兰华沙地区 DDH 的发病率为 3.73 至 5.17(95%CI)。根据多变量分析,DDH 的危险因素为出生体重(OR=2.17(1.41−3.32))、分娩周数(OR=1.18(1.00−1.37))、女性性别(OR=8.16(4.86−13.71))、臀位(OR=5.92(3.37−10.40))、DDH 的体格检查阳性(OR=25.28(8.77−72.83))和兄弟姐妹中有阳性家族史(OR=5.74(2.68−12.31))。我们的结果支持最近的假说,即早产儿(<37 周)的 DDH 发生率较低。

结论

使用多变量逻辑回归预测模型构建了风险计算器。DDH 风险计算器将在前瞻性验证研究中进行评估。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d94/9502116/6d1ce0fb7690/medicina-58-01158-g001.jpg

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