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研究蝙蝠相关病原体的分子方法的机遇与局限

Opportunities and Limitations of Molecular Methods for Studying Bat-Associated Pathogens.

作者信息

Zemanová Silvia, Korytár Ľuboš, Tomčová Jana, Prokeš Marián, Drážovská Monika, Myczko Łukasz, Tryjanowski Piotr, Nusová Gréta, Matysiak Alicja, Ondrejková Anna

机构信息

Department of Epizootiology, Parasitology and Protection of One Health, University of Veterinary Medicine and Pharmacy in Košice, 041 81 Košice, Slovakia.

Department of Zoology, Poznań University of Life Sciences, 60-625 Poznań, Poland.

出版信息

Microorganisms. 2022 Sep 19;10(9):1875. doi: 10.3390/microorganisms10091875.

Abstract

Bats have been identified as reservoirs of zoonotic and potentially zoonotic pathogens. Significant progress was made in the field of molecular biology with regard to infectious diseases, especially those that infect more than one species. Molecular methods, sequencing and bioinformatics have recently become irreplaceable tools in emerging infectious diseases research and even outbreak prediction. Modern methods in the molecular biology field have shed more light on the unique relationship between bats and viruses. Here we provide readers with a concise summary of the potential and limitations of molecular methods for studying the ecology of bats and bat-related pathogens and microorganisms.

摘要

蝙蝠已被确认为人畜共患病和潜在人畜共患病病原体的宿主。在传染病领域,尤其是那些感染多种物种的传染病方面,分子生物学取得了重大进展。分子方法、测序和生物信息学最近已成为新发传染病研究乃至疫情预测中不可替代的工具。分子生物学领域的现代方法使人们对蝙蝠与病毒之间的独特关系有了更多了解。在此,我们为读者简要总结了用于研究蝙蝠生态学以及与蝙蝠相关的病原体和微生物的分子方法的潜力和局限性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6074/9502413/708c3c6233e6/microorganisms-10-01875-g001.jpg

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