一种 Carabrane 型倍半萜烯内酯化合物 Carabrone 通过诱导铁死亡抑制 SW1990 胰腺癌细胞。
A Carabrane-Type Sesquiterpenolide Carabrone from Inhibits SW1990 Pancreatic Cancer Cells by Inducing Ferroptosis.
机构信息
College of Life Science, Northwest Normal University, Lanzhou 730070, China.
CAS Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, China.
出版信息
Molecules. 2022 Sep 9;27(18):5841. doi: 10.3390/molecules27185841.
Pancreatic cancer has an extremely poor prognosis, and the clinical drugs for the treatment of pancreatic cancer are usually multi-drug combinations. Therefore, it is necessary to search for and find specific new bioactive agents against pancreatic cancer. Carabrone is a carabrane-type sesquiterpenolide extracted from L., and this natural compound has been reported to be a potential anti-tumor agent. However, there are few reports on the function of carabrone related to anti-tumor activity in pancreatic cancer. Herein, cell experiments indicated that carabrone had anti-proliferation inhibition and anti-migration and anti-invasion activity against SW1990 cells. Furthermore, the tandem mass spectrometry and network pharmacology analysis showed that this activity may be related to the ferroptosis and Hippo signaling pathway. Taken together, our results demonstrated that carabrone exhibited prominent anti-pancreatic cancer activity and could be a promising agent against pancreatic cancer.
胰腺癌预后极差，用于治疗胰腺癌的临床药物通常是多种药物的联合应用。因此，有必要寻找并发现针对胰腺癌的特异性新型生物活性药物。Carabrone 是从 L. 中提取的一种卡波烷型倍半萜烯醇，这种天然化合物已被报道为一种有潜力的抗肿瘤药物。然而，关于 Carabrone 与胰腺癌的抗肿瘤活性相关的功能的报道很少。在此，细胞实验表明，Carabrone 对 SW1990 细胞具有抗增殖抑制、抗迁移和抗侵袭活性。此外，串联质谱和网络药理学分析表明，这种活性可能与铁死亡和 Hippo 信号通路有关。综上所述，我们的结果表明，Carabrone 表现出显著的抗胰腺癌活性，可能是一种有前途的胰腺癌治疗药物。
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