文献检索文档翻译深度研究
Suppr Zotero 插件Zotero 插件
邀请有礼套餐&价格历史记录

新学期，新优惠

限时优惠:9月1日-9月22日

30天高级会员仅需29元

1天体验卡首发特惠仅需5.99元

了解详情
不再提醒
插件&应用
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
高级版
套餐订阅购买积分包
AI 工具
文献检索文档翻译深度研究
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2025

Peptide Shuttles for Blood-Brain Barrier Drug Delivery.

作者信息

Sánchez-Navarro Macarena, Giralt Ernest

机构信息

Department of Molecular Biology, Instituto de Parasitología y Biomedicina ''López Neyra" (CSIC), 18016 Granada, Spain.

Institute for Research in Biomedicine (IRB Barcelona), Barcelona Institute of Science and Technology (BIST), Baldiri Reixac 10, 08028 Barcelona, Spain.

出版信息

Pharmaceutics. 2022 Sep 5;14(9):1874. doi: 10.3390/pharmaceutics14091874.

DOI:10.3390/pharmaceutics14091874
PMID:36145622
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9505527/
Abstract

The blood-brain barrier (BBB) limits the delivery of therapeutics to the brain but also represents the main gate for nutrient entrance. Targeting the natural transport mechanisms of the BBB offers an attractive route for brain drug delivery. Peptide shuttles are able to use these mechanisms to increase the transport of compounds that cannot cross the BBB unaided. As peptides are a group of biomolecules with unique physicochemical and structural properties, the field of peptide shuttles has substantially evolved in the last few years. In this review, we analyze the main classifications of BBB-peptide shuttles and the leading sources used to discover them.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9974/9505527/5a2eabca46a9/pharmaceutics-14-01874-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9974/9505527/6b8a3394a4f8/pharmaceutics-14-01874-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9974/9505527/5a2eabca46a9/pharmaceutics-14-01874-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9974/9505527/6b8a3394a4f8/pharmaceutics-14-01874-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9974/9505527/5a2eabca46a9/pharmaceutics-14-01874-g002.jpg

相似文献

[1]
Peptide Shuttles for Blood-Brain Barrier Drug Delivery.

Pharmaceutics. 2022-9-5

[2]
Jumping Hurdles: Peptides Able To Overcome Biological Barriers.

Acc Chem Res. 2017-7-17

[3]
'À la carte' peptide shuttles: tools to increase their passage across the blood-brain barrier.

ChemMedChem. 2014-7

[4]
Lipid bilayer crossing--the gate of symmetry. Water-soluble phenylproline-based blood-brain barrier shuttles.

J Am Chem Soc. 2015-6-2

[5]
Chemically synthesized peptide libraries as a new source of BBB shuttles. Use of mass spectrometry for peptide identification.

J Pept Sci. 2016-9

[6]
Peptide Mediated Brain Delivery of Nano- and Submicroparticles: A Synergistic Approach.

Curr Pharm Des. 2018

[7]
Blood-brain barrier peptide shuttles.

Curr Opin Chem Biol. 2017-6

[8]
Branched BBB-shuttle peptides: chemoselective modification of proteins to enhance blood-brain barrier transport.

Chem Sci. 2018-9-18

[9]
Brain penetrating peptides and peptide-drug conjugates to overcome the blood-brain barrier and target CNS diseases.

Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2021-7

[10]
Peptide-mediated drug delivery across the blood-brain barrier for targeting brain tumors.

Expert Opin Drug Deliv. 2019-5-20

引用本文的文献

[1]
A comprehensive insight of innovations and recent advancements in nanocarriers for nose-to-brain drug targeting.

Des Monomers Polym. 2025-2-10

[2]
Lanthanide-tetrazine probes for bio-imaging and click chemistry.

Chem Sci. 2025-1-22

[3]
The Importance of Phosphoinositide 3-Kinase in Neuroinflammation.

Int J Mol Sci. 2024-10-30

[4]
Discovery of a Novel Dual Targeting Peptide for Human Glioma: From Simulation to Acting as Targeting Ligand.

Adv Pharm Bull. 2024-7

[5]
Molecular determinants for brain targeting by peptides: a meta-analysis approach with experimental validation.

Fluids Barriers CNS. 2024-5-27

[6]
Receptor-Assisted Nanotherapeutics for Overcoming the Blood-Brain Barrier.

Mol Neurobiol. 2024-11

[7]
Calming the Nerves via the Immune Instructive Physiochemical Properties of Self-Assembling Peptide Hydrogels.

Adv Sci (Weinh). 2024-2

[8]
Topoisomeric Membrane-Active Peptides: A Review of the Last Two Decades.

Pharmaceutics. 2023-10-12

[9]
A Promising Approach: Magnetic Nanosystems for Alzheimer's Disease Theranostics.

Pharmaceutics. 2023-9-13

[10]
Differential Blood-Brain Barrier Transport and Cell Uptake of Cyclic Peptides In Vivo and In Vitro.

Pharmaceutics. 2023-5-16

本文引用的文献

[1]
Conjugation of a Blood Brain Barrier Peptide Shuttle to an Fc Domain for Brain Delivery of Therapeutic Biomolecules.

ACS Med Chem Lett. 2021-9-2

[2]
BBPpredict: A Web Service for Identifying Blood-Brain Barrier Penetrating Peptides.

Front Genet. 2022-5-17

[3]
A Tumor-Homing Peptide Platform Enhances Drug Solubility, Improves Blood-Brain Barrier Permeability and Targets Glioblastoma.

Cancers (Basel). 2022-4-28

[4]
Homogeneous antibody-angiopep 2 conjugates for effective brain targeting.

RSC Adv. 2022-1-26

[5]
Biological Membrane-Penetrating Peptides: Computational Prediction and Applications.

Front Cell Infect Microbiol. 2022

[6]
Targeting Transporters for Drug Delivery to the Brain: Can We Do Better?

Pharm Res. 2022-7

[7]
Kinetics of Blood-Brain Barrier Transport of Monoclonal Antibodies Targeting the Insulin Receptor and the Transferrin Receptor.

Pharmaceuticals (Basel). 2021-12-21

[8]
Customized blood-brain barrier shuttle peptide to increase AAV9 vector crossing the BBB and augment transduction in the brain.

Biomaterials. 2022-2

[9]
Protease-Resistant Peptides for Targeting and Intracellular Delivery of Therapeutics.

Pharmaceutics. 2021-12-2

[10]
The RaPID Platform for the Discovery of Pseudo-Natural Macrocyclic Peptides.

Acc Chem Res. 2021-9-21

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

推荐工具

医学文档翻译智能文献检索