血脑屏障肽转运体
Blood-brain barrier peptide shuttles.
作者信息
Sánchez-Navarro Macarena, Giralt Ernest, Teixidó Meritxell
机构信息
Institute for Research in Biomedicine-Barcelona Institute of Science and Technology, Baldiri Reixac 10, 08028 Barcelona, Spain.
Institute for Research in Biomedicine-Barcelona Institute of Science and Technology, Baldiri Reixac 10, 08028 Barcelona, Spain; Department of Organic Chemistry, University of Barcelona, Spain.
出版信息
Curr Opin Chem Biol. 2017 Jun;38:134-140. doi: 10.1016/j.cbpa.2017.04.019. Epub 2017 May 27.
Brain delivery is hampered by the presence of the blood-brain barrier (BBB), a natural defence of the brain that protects it and allows the entrance of nutrients by several mechanisms. Taking advantage of these mechanisms is an opportunity to treat brain related diseases. Among the different alternatives, BBB peptide shuttles are gaining attention to increase brain delivery of therapeutics. The most recent advances in the field are analysed here.
血脑屏障（BBB）的存在阻碍了药物向脑部的递送，血脑屏障是大脑的一种天然防御机制，它保护大脑，并通过多种机制允许营养物质进入。利用这些机制是治疗脑部相关疾病的一个契机。在不同的方法中，BBB肽转运体正受到关注，以提高治疗药物向脑部的递送。本文分析了该领域的最新进展。
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