疫苗接种状况和疫苗接种剂量数与新冠病毒肺炎住院患者入院时的氧合指数独立相关。
Vaccination Status and Number of Vaccine Doses Are Independently Associated with the PaO/FiO Ratio on Admission in Hospitalized COVID-19 Patients.
作者信息
Zinellu Elisabetta, Zinellu Angelo, Merella Michela, Mangoni Arduino A, Pau Maria Carmina, Fois Sara S, Fois Alessandro G, Carru Ciriaco, Pirina Pietro
机构信息
Clinical and Interventional Pneumology, University Hospital of Sassari (AOU), 07100 Sassari, Italy.
Department of Biomedical Sciences, University of Sassari, 07100 Sassari, Italy.
出版信息
Vaccines (Basel). 2022 Aug 29;10(9):1424. doi: 10.3390/vaccines10091424.
INTRODUCTION
Coronavirus Disease-19 (COVID-19) vaccines reduce the risk of severe disease and mortality. However, the association between vaccination status and number of doses and the PaO/FiO ratio, a clinical measure of hypoxemia associated with an increased risk of intensive care treatment and mortality, has not been investigated.
METHODS
We retrospectively assessed a consecutive series of 116 patients admitted to hospital with a primary diagnosis of COVID-19 between January and April 2022. Demographic, clinical, and laboratory data were collected within 24 h from admission.
RESULTS
There was a significant positive relationship between the number of vaccine doses and the PaO/FiO ratio (r = 0.223, = 0.012). This association remained significant after adjusting for confounders. Vaccinated patients had significantly higher PaO/FiO ratios than the unvaccinated (median: 250; IQR: 195-309 vs. 200; IQR: 156-257, = 0.013).
CONCLUSION
These results highlight the importance of the number of vaccine doses received in reducing the degree of hypoxia on admission in hospitalized COVID-19 patients.
引言
新型冠状病毒肺炎（COVID-19）疫苗可降低重症疾病和死亡风险。然而，疫苗接种状态、接种剂量与动脉血氧分压/吸入氧分数值（PaO/FiO）之间的关联尚未得到研究，PaO/FiO是一种与重症监护治疗风险和死亡率增加相关的低氧血症临床指标。
方法
我们回顾性评估了2022年1月至4月期间连续收治的116例以COVID-19为主要诊断入院的患者。在入院后24小时内收集人口统计学、临床和实验室数据。
结果
疫苗接种剂量与PaO/FiO之间存在显著正相关（r = 0.223，P = 0.012）。在调整混杂因素后，这种关联仍然显著。接种疫苗的患者的PaO/FiO显著高于未接种疫苗的患者（中位数：250；四分位间距：195 - 309 vs. 200；四分位间距：156 - 257，P = 0.013）。
结论
这些结果凸显了接种疫苗剂量在降低住院COVID-19患者入院时低氧程度方面的重要性。
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