Maulana Muhammad Bintang, Fuadi Muhamad Robi'ul
Study Program of Clinical Pathology, Department of Clinical Pathology, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia.
Department of Clinical Pathology, Faculty of Medicine, Universitas Airlangga - Dr. Soetomo General Academic Hospital, Surabaya, Indonesia.
Ann Med Surg (Lond). 2022 Aug 24;81:104454. doi: 10.1016/j.amsu.2022.104454. eCollection 2022 Sep.
Thalassemia is categorized based on the abnormal globin chain and is divided into primary, intermediate, and minor subtypes based on the chain abnormality, respectively.
An Indonesian adolescent, 18 years old, complained of abdominal pain for 1-day. Medical history patient showed thalassemia for 13 years, routine control and received transfusions. Physical examination: Anemic conjunctiva (+/+), epigastric tenderness (+). Laboratory tests: Hb of 4.2 g/dL, MCV of 59.8 fL, and MCH of 19.6 pg. Peripheral blood smears showed microcytic hypochromic, target cells, and teardrop cells. Increased albumin: creatinine ratio ≥300 mg/gr. Hb Electrophoresis showed increased HbF and HbA2 fractions. Abdominal Ultrasound showed cholelithiasis. The patient performed laparoscopic cholecystectomy and was successful.
Cholelithiasis is often found in thalassemia intermedia complications. Regular ultrasound examination in β-Thalassemia is used to detect cholelithiasis.
Clinical pathology analysis supports the diagnosis of cholelithiasis in the β-Thalassemia patient.
地中海贫血根据异常珠蛋白链进行分类，并分别根据链异常分为主要、中间和轻度亚型。
一名18岁的印度尼西亚青少年，主诉腹痛1天。患者病史显示患地中海贫血13年，定期检查并接受输血治疗。体格检查：结膜贫血（++），上腹部压痛（+）。实验室检查：血红蛋白4.2g/dL，平均红细胞体积59.8fL，平均红细胞血红蛋白含量19.6pg。外周血涂片显示小细胞低色素性、靶形细胞和泪滴状细胞。白蛋白：肌酐比值升高≥300mg/gr。血红蛋白电泳显示血红蛋白F和血红蛋白A2分数升高。腹部超声显示胆结石。患者接受了腹腔镜胆囊切除术，手术成功。
胆结石常见于中间型地中海贫血并发症。β地中海贫血患者需定期进行超声检查以检测胆结石。
临床病理分析支持β地中海贫血患者胆结石的诊断。
