Kyriakidis Ioannis, Palabougiouki Maria, Vasileiou Eleni, Tragiannidis Athanasios, Stamou Maria, Moudiou Tatiani, Vyzantiadis Timoleon, Gombakis Nikolaos, Hatzistilianou Maria
Department of Pediatrics, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Department of Microbiology, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Turk Pediatri Ars. 2019 Jul 11;54(2):129-132. doi: 10.14744/TurkPediatriArs.2019.67674. eCollection 2019.
Both biliary atresia and hemoglobinopathies have been associated with a higher incidence of bloodstream infections. We hereby present the case of a female infant of Nigerian descent with extrahepatic biliary atresia and double heterozygocity for sickle cell disease and alpha-thalassemia. Kasai hepatoportoenterostomy was performed in the child's sixth week of life. Bloodstream infections occurred two months post-hepatoportoenterostomy, even though the infant was still in prophylactic antibiotic treatment: the first was due to Candida albicans and was followed by bacteremia due to Escherichia coli. A third infection, confined to the skin only, was due to Acinetobacter spp. Treatment options, predisposing factors, and the pathophysiology of bloodstream infections in patients with biliary atresia and aberrant hemoglobin are discussed herein.
胆道闭锁和血红蛋白病都与血流感染的较高发生率相关。我们在此报告一例尼日利亚裔女婴，患有肝外胆道闭锁，同时为镰状细胞病和α地中海贫血的双重杂合子。在患儿出生后第六周进行了Kasai肝门肠吻合术。肝门肠吻合术后两个月发生了血流感染，尽管该婴儿仍在接受预防性抗生素治疗：第一次感染是由白色念珠菌引起的，随后是由大肠杆菌引起的菌血症。第三次感染仅局限于皮肤，是由不动杆菌属引起的。本文讨论了胆道闭锁和异常血红蛋白患者血流感染的治疗选择、易感因素及病理生理学。
