中性粒细胞与淋巴细胞比值（NLR）在阴茎癌中的预后价值：一项系统评价和荟萃分析

Prognostic value of neutrophil-to-lymphocyte ratio (NLR) in penile cancer: A systematic review and meta-analysis.

作者信息

Saputra Haviv Muris, Hidayatullah Furqan, Kloping Yudhistira Pradnyan, Renaldo Johan, Chung Eric, Hakim Lukman

机构信息

Department of Urology, Faculty of Medicine, Universitas Airlangga, Surabaya, East Java, Indonesia.

Dr. Soetomo General-Academic Hospital, Surabaya, East Java, Indonesia.

出版信息

Ann Med Surg (Lond). 2022 Aug 5;81:104335. doi: 10.1016/j.amsu.2022.104335. eCollection 2022 Sep.

BACKGROUND

Penile cancer is rare among male malignancies. Various biomarkers have been used to predict the prognosis of cancer, one of which is the neutrophil to lymphocyte ratio (NLR). Therefore, we conducted this systematic review and meta-analysis to evaluate the prognostic value of NLR in penile cancer.

METHODS

This review was conducted following the PRISMA guideline. Several databases, including Scopus, Science-direct, and PubMed, were systematically searched. The primary outcomes were lymph node metastasis (LNM), cancer-specific survival (CSS), and overall survival (OS). All statistical analyses were processed using Review Manager (RevMan) version 5.4.

RESULTS

A total of six retrospective studies were included in the analysis. The cut-off values of NLR in the included studies ranged from 2.6 to 3.59. Meta-analysis showed that penile cancer patients with high NLR had worse LNM and CSS based on the univariate analysis (OR 3.56, 95% CI 2.38, 5.32, p < 0.01; HR 4.19, 95% CI 2.19, 8.01, p = 0.0; respectively). Furthermore, the meta-analysis revealed that NLR is an independent predictor of LNM and CSS (OR 6.67, 95% CI 2.44, 18.22, p < 0.01; HR 2.15, 95% CI 1.23, 3.73, p < 0.01; respectively). However, NLR failed to show as independent predictor for OS (HR 1.69,95% CI 0.95,3.00, p = 0.07).

CONCLUSION

NLR is an independent predictor of LNM and CSS. However, NLR is not proven to be an independent predictor of OS in this study.

背景

阴茎癌在男性恶性肿瘤中较为罕见。多种生物标志物已被用于预测癌症预后，其中之一是中性粒细胞与淋巴细胞比值（NLR）。因此，我们进行了这项系统评价和荟萃分析，以评估NLR在阴茎癌中的预后价值。

方法

本评价遵循PRISMA指南进行。对包括Scopus、ScienceDirect和PubMed在内的多个数据库进行了系统检索。主要结局指标为淋巴结转移（LNM）、癌症特异性生存（CSS）和总生存（OS）。所有统计分析均使用Review Manager（RevMan）5.4版进行。

结果

分析共纳入6项回顾性研究。纳入研究中NLR的截断值范围为2.6至3.59。荟萃分析显示，基于单因素分析，NLR高的阴茎癌患者LNM和CSS较差（OR 3.56，95%CI 2.38，5.32，p<0.01；HR 4.19，95%CI 2.19，8.01，p = 0.0；分别）。此外，荟萃分析显示NLR是LNM和CSS的独立预测因子（OR 6.67，95%CI 2.44，18.22，p<0.01；HR 2.15，95%CI 1.23，3.73，p<0.01；分别）。然而，NLR未能显示为OS的独立预测因子（HR 1.69，95%CI 0.95，3.00，p = 0.07）。