印度南部一家三级护理医院中他汀类药物的使用与糖尿病视网膜病变进展的关联。
Association of Use of Statins with Progression of Diabetic Retinopathy at a Tertiary Care Hospital in Southern India.
作者信息
Priyadarshini Prachi, Chogtu Bharti, Bhandary Sulatha V, Magazine Rahul
机构信息
Boehringer, Ingelheim, Bangalore, Karnataka, India.
Department of Pharmacology, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, India.
出版信息
J Curr Ophthalmol. 2022 Jul 26;34(2):234-240. doi: 10.4103/joco.joco_70_21. eCollection 2022 Apr-Jun.
PURPOSE
To study the role of statin therapy on diabetic retinopathy (DR) progression.
METHODS
This retrospective study was carried out at a tertiary care hospital in southern India. Data were collected from the medical records of patients admitted from January 2013 to December 2018. Out of 1673 patients of DR enrolled in the study, 171 met the inclusion criteria. Patients' demographic data, drug history, clinical characteristics, and laboratory investigations were recorded as per the pro forma. The patients were divided into statin users and nonusers. The results were analyzed to compare the DR progression between the two groups.
RESULTS
DR progressed in 67% of nonstatin users and 37% of statin users ( < 0.001). The use of statins decreased the risk of DR progression ( < 0.001). Center-involving macular edema was seen in 8 of 79 statin users (10%) and 16 of 92 statin nonusers (16%) based on optical coherence tomography findings during the follow-up period ( = 0.17).
CONCLUSION
In patients with type 2 diabetes, lipid-lowering therapy with statins has the potential to retard DR progression.
目的
研究他汀类药物治疗对糖尿病视网膜病变（DR）进展的作用。
方法
这项回顾性研究在印度南部的一家三级护理医院进行。数据从2013年1月至2018年12月入院患者的病历中收集。在纳入研究的1673例DR患者中，171例符合纳入标准。按照表格形式记录患者的人口统计学数据、用药史、临床特征和实验室检查结果。将患者分为他汀类药物使用者和非使用者。分析结果以比较两组之间的DR进展情况。
结果
67%的非他汀类药物使用者和37%的他汀类药物使用者出现DR进展（<0.001）。使用他汀类药物降低了DR进展的风险（<0.001）。根据随访期间光学相干断层扫描结果，79例他汀类药物使用者中有8例（10%）出现累及中心凹的黄斑水肿，92例非他汀类药物使用者中有16例（16%）出现（P = 0.17）。
结论
在2型糖尿病患者中，他汀类药物降脂治疗有可能延缓DR进展。
Zotero 插件