Alizadeh Yousef, Akbari Mitra, Moghadam Reza Soltani, Dourandeesh Maryam, Moravej Zahra
Eye Research Center, Department of Eye, Amiralmomenin Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
J Curr Ophthalmol. 2022 Jul 26;34(2):208-215. doi: 10.4103/joco.joco_285_21. eCollection 2022 Apr-Jun.
To evaluate the efficacy of 3-month administration of topical cyclosporin A (CsA) 0.05% on postoperative recurrence after pterygium surgery.
In this randomized clinical trial, 78 patients undergoing pterygium surgery (using the rotational conjunctival flap technique with mitomycin C [MMC]) were enrolled and randomly allocated into the control ( = 39) and case (CsA) ( = 39) groups in a single-blind method. The patients were examined on postoperative days 1, 3, and 7 and months 1, 3, and 6, and their best-corrected visual acuity, intraocular pressure, clinical inflammation, postoperative complications, and recurrence were compared.
The mean age of patients was 53.22 ± 9.99 years; most (57.7%) of them were men. The two groups were not different in terms of demographics, pterygium size, or pterygium grade. The clinical inflammation at the first and third postoperative months was not different between the groups ( = 0.108 and 0.780, respectively). No serious complications were detected; complication rates were not different between the groups ( = 0.99). The recurrence rate was 5.1% in the case group and 7.7%% in the control group ( = 0.99).
The present study showed no priority for 3-month administration of CsA 0.05% drops on postoperative outcomes, including prevention of pterygium recurrence, complications, and inflammation after the rotational conjunctival autograft technique with MMC.
评估0.05%的局部用环孢素A（CsA）给药3个月对翼状胬肉手术后复发的疗效。
在这项随机临床试验中，纳入78例行翼状胬肉手术（采用含丝裂霉素C [MMC]的旋转结膜瓣技术）的患者，并采用单盲法将其随机分为对照组（n = 39）和病例组（CsA）（n = 39）。在术后第1天、第3天、第7天以及第1个月、第3个月和第6个月对患者进行检查，比较他们的最佳矫正视力、眼压、临床炎症、术后并发症及复发情况。
患者的平均年龄为53.22±9.99岁；其中大多数（57.7%）为男性。两组在人口统计学、翼状胬肉大小或翼状胬肉分级方面无差异。术后第1个月和第3个月时两组的临床炎症无差异（分别为P = 0.108和0.780）。未检测到严重并发症；两组的并发症发生率无差异（P = 0.99）。病例组的复发率为5.1%，对照组为7.7%（P = 0.99）。
本研究表明，对于采用含MMC的旋转结膜自体移植技术后的术后结局，包括预防翼状胬肉复发、并发症和炎症，局部滴用0.05%的CsA 3个月并无优势。
